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Tetrahydrocannabivarin (THCV) Dose Dependently Blocks or Substitutes for Tetrahydrocannabinol (THC) in a Drug Discrimination Task in Rats [PDF]
BiomoleculesDelta-9-Tetrahydrocannabivarin (THCV), a naturally occurring cannabinoid and structural analog of THC, exhibits a dual pharmacological profile as a CB1 receptor agonist/antagonist and a partial CB2 agonist.
Hakan Kayir +3 more
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Addictive Behaviors Reports, 2023 Objectives: Our objective is to determine if specific sociodemographic characteristics were associated with perceived drug-related discrimination among people who use drugs (PWUD) presenting for care in the emergency department (ED).
Shayla Nolen +5 more
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Drug and Alcohol Dependence Reports, 2023 Aims: Benzofurans are used recreationally, due their ability to cause psychostimulant and/or entactogenic effects, but unfortunately produce substantial adverse effects, including death. Three benzofurans 5-(2-aminopropyl)-2,3-dihydrobenzofuran (5-APDB),
Rebecca D. Hill +4 more
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Frontiers in Pharmacology, 2019 Hypofunction of the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) has been implicated in a variety of disorders including substance use disorders. As such, approaches to enhance 5-HT2CR signaling display therapeutic potential.
Claudia A. Soto +7 more
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Drug discrimination of Near Infrared spectroscopy based on the scaled convex hull classifier [PDF]
Journal of Innovative Optical Health Sciences, 2014 Near Infrared spectroscopy (NIRS) has been widely used in the discrimination (classification) of pharmaceutical drugs. In real applications, however, the class imbalance of the drug samples, i.e., the number of one drug sample may be much larger than the
Zhenbing Liu, Shujie Jiang, Huihua Yang
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Are “no-drug” cues discriminated during drug-discrimination training? [PDF]
Animal Learning & Behavior, 1983 Rats were trained in a two-lever operant chamber to discriminate the presence versus the absence of a drug. During drug sessions, the training procedure involved reinforcing presses on lever 1 with saccharin-sweetened water but not reinforcing presses on lever 2. During no-drug sessions, only presses on lever 2 were reinforced.
Donald A. Overton +2 more
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Ecological Momentary Assessment of Daily Discrimination Experiences and Nicotine, Alcohol, and Drug Use Among Sexual and Gender Minority Individuals [PDF]
, 2017 Objective: Sexual and gender minority (SGM) individuals experience elevated rates of minority stress, which has been linked to higher rates of nicotine and substance use.
Cochran, Bryan N. +4 more
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Scientific Reports, 2022 Label-free image analysis has several advantages with respect to the development of drug screening platforms. However, the evaluation of drug-responsive cells based exclusively on morphological information is challenging, especially in cases of ...
Yuta Imai +4 more
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Ligand-based virtual screening using binary kernel discrimination [PDF]
, 2005 This paper discusses the use of a machine-learning technique called binary kernel discrimination (BKD) for virtual screening in drug- and pesticide-discovery programmes.
Beining Chen +14 more
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Behavioral Sciences, 2012 Stress enhances the behavioral effects of cocaine, perhaps via hypothalamic-pituitary-adrenal (HPA) axis activity. Yet, compared to Fischer 344 (F344) rats, Lewis rats have hyporesponsive HPA axis function and more readily acquire cocaine self ...
Therese A. Kosten +1 more
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