Results 21 to 30 of about 516,097 (212)

Detection of the ABCB11930_1931del TC Mutation in Two Suspected Ivermectin-Sensitive Cats and Their Relatives by a Novel TaqMan Allelic Discrimination Assay

Frontiers in Veterinary Science, 2022
The multidrug resistance gene MDR1 (syn. ABCB1) encodes for the multidrug efflux transporter P-glycoprotein (P-gp), which is highly expressed at the blood-brain barrier and protects the brain from potentially neurotoxic compounds, such as ivermectin ...
Daniela Nürnberger, Lisa Wagner, Simon F. Müller, Silke Leiting, Regina Leidolf, Jörg Alber, Melanie Hamann, Joachim Geyer   +7 more
doaj   +1 more source

Locomotor and discriminative stimulus effects of N-cyclohexyl butylone and N-cyclohexyl methylone

Frontiers in Pharmacology
BackgroundN-Cyclohexyl butylone and N-cyclohexyl methylone are cathinones found on the street that produce morbidity and mortality, but are not yet legally controlled, and there has been little or no pharmacological testing of these compounds.
Michael B. Gatch, Shuping Jia, Ritu A. Shetty, Rebecca D. Hill, Nathalie Sumien, Michael J. Forster   +5 more
doaj   +1 more source

The effects of kappa opioid agonist RU-1205 on local field potentials and behavior in the discriminative stimulus paradigm

Фармация и фармакология (Пятигорск)
Kappa opioid receptors play a pivotal role in regulating both physiological and cognitive processes. RU-1205, a benzimidazole derivative acting as a specific kappa opioid receptor agonist, has demonstrated the capacity to modulate neuronal activity ...
K. Yu. Kalitin, O. Yu. Mukha, A. A. Spasov   +2 more
doaj   +1 more source

Experiencing discrimination increases risk taking. [PDF]

, 2013
Prior research has revealed racial disparities in health outcomes and health-compromising behaviors, such as smoking and drug abuse. It has been suggested that discrimination contributes to such disparities, but the mechanisms through which this might ...
Jamieson, Jeremy P, Koslov, Katrina, Mendes, Wendy Berry, Nock, Matthew K   +3 more
core   +1 more source

Evaluation of machine-learning methods for ligand-based virtual screening [PDF]

, 2007
Machine-learning methods can be used for virtual screening by analysing the structural characteristics of molecules of known (in)activity, and we here discuss the use of kernel discrimination and naive Bayesian classifier (NBC) methods for this purpose ...
A Bender, A Bender, A Bender, A Ormerod, A Ormerod, AE Klon, AM Capelli, AR Leach, B Chen, Beining Chen, C Williams, D Hand, D Rogers, D Wilton, DA Cosgrove, David J. Wood, DB Kitchen, DE Clark, DJ Hand, DJ Wilton, DM Hawkins, E Parzen, FL Stahura, G Harper, G Redl, G Schneider, George Papadatos, H Eckert, H Kubinyi, HM Berman, J Aitchison, J Bajorath, J Delaney, J Hert, J Hert, J Hert, JC Saeh, L Hodes, L Hodes, L Hodes, M Congreve, M Glick, M Glick, M Wagener, M Whittle, N Christianini, N Nikolova, Nikolaus Stiefl, P Constans, P Domingos, P Willett, P Willett, P Willett, P Willett, P Willett, Paulette Greenidge, Peter Willett, Q Zhang, R P Sheridan, RD Brown, RD Brown, RD Cramer, RE Carhart, RO Duda, Robert F. Harrison, S Anzali, TJ McNeany, TM Mitchell, Xiao Qing Lewell, XY Xia, YC Martin, YC Martin   +71 more
core   +2 more sources

Drug discrimination in pigeons trained to discriminate among morphine, U50488, a combination of these drugs, and saline [PDF]

Behavioural Pharmacology, 2011
This study compared fixed-ratio (FR) and fixed-interval (FI) schedules to investigate the discriminative stimulus properties of μ-opioid and/or κ-opioid receptor agonists. Pigeons were trained to discriminate among morphine (μ agonist), U50488 (κ agonist), the combination, and saline under FR 20-s or FI-300-s schedule.
William D, Wessinger, Mi, Li, Donald E, McMillan   +2 more
openaire   +2 more sources

Who feels safe calling 911: are prior experiences of anti-Black racial discrimination associated with hesitancy seeking emergency medical services in the event of accidental drug overdose? – a study protocol

Annals of Medicine
Background Racial discrimination is associated with health disparities among Black Americans, a group that has experienced an increase in rates of fatal drug overdose.
O. Trent Hall, Candice Trimble, Stephanie Garcia, Sydney Grayson, Lucy Joseph, Parker Entrup, Oluwole Jegede, Jose Perez Martel, Jeanette Tetrault, Myra Mathis, Ayana Jordan   +10 more
doaj   +1 more source

Conceptualizing cancer drugs as classifiers. [PDF]

PLoS ONE, 2014
Cancer and healthy cells have distinct distributions of molecular properties and thus respond differently to drugs. Cancer drugs ideally kill cancer cells while limiting harm to healthy cells. However, the inherent variance among cells in both cancer and
Patrick Nathan Lawlor, Tomer Kalisky, Robert Rosner, Marsha Rich Rosner, Konrad Paul Kording   +4 more
doaj   +1 more source

Antagonism of a PCP Drug Discrimination by Hallucinogens and Related Drugs [PDF]

Neuropsychopharmacology, 2000
Drugs such as PCP and MK-801 can cause psychotic reactions in humans by antagonizing NMDA receptors. This action is ultimately toxic to certain cortical neurons and may be one mechanism underlying neurodegenerative diseases, including schizophrenia. It has been reported that hallucinogens such as LSD, DOM, and DOI can block the neurotoxic effects of ...
W B, West, A, Lou, K, Pechersky, M E, Chachich, J B, Appel   +4 more
openaire   +2 more sources

Stigma and substance use disorders: A contextual review from an Indian perspective

Annals of Indian Psychiatry, 2020
The prevalence of substance use disorders is on an upsurge in the Indian population. Unfortunately, they remain one of the most under reported and undertreated medical conditions.
Udit Kumar Panda, Soumya Swaroop Sahoo, Romil Saini   +2 more
doaj   +1 more source