Results 11 to 20 of about 516,097 (212)

Neurosteroid effects on sensitivity to ethanol

Frontiers in Endocrinology, 2012
Harrison and Simmonds (1984) provided the first clear evidence that neuroactive steroids act at specific neurotransmitter receptors, investigating the potentiation of muscimol-induced GABAA responses by alphaxalone (3α-hydroxy 5α -pregnane l l,20-dione ...
Christa M Helms, David eRossi, Kathleen A Grant, Kathleen A Grant   +3 more
doaj   +1 more source

Perceived barriers to psychiatric help-seeking in South Korea by age groups: text mining analyses of social media big data

BMC Psychiatry, 2022
Background The psychiatric treatment gap is substantial in Korea, implying barriers in seeking help. Objectives This study aims to explore barriers of seeing psychiatrists, expressed on the internet by age groups.
Hwo Yeon Seo, Gil Young Song, Jee Won Ku, Hye Yoon Park, Woojae Myung, Hee Jung Kim, Chang Hyeon Baek, Nami Lee, Jee Hoon Sohn, Hee Jeong Yoo, Jee Eun Park   +10 more
doaj   +1 more source

Development and validation of the nomogram to predict the risk of hospital drug shortages: A prediction model.

PLoS ONE, 2023
IntroductionReasons for drug shortages are multi-factorial, and patients are greatly injured. So we needed to reduce the frequency and risk of drug shortages in hospitals.
Jie Dong, Yang Gao, Yi Liu, Xiuling Yang
doaj   +1 more source

Detection of H275Y Mutation Conferring Oseltamivir Drug Resistance in Influenza A (H1N1) pdm09 Virus

Journal of Pure and Applied Microbiology, 2021
In the treatment of influenza, Neuraminidase inhibitors (NAIs) (Oseltamivir and Zanamivir) play a major role. The emergence of variants of influenza A (H1N1) pdm09 virus resistant to Oseltamivir is a matter of great concern as it limits its usage ...
Khushbu Trivedi, Bharti Malhotra, Widhi Dubey, Pratibha Sharma, Farah Deeba, Jitendra Tiwari, Aradhana Chauhan   +6 more
doaj   +1 more source

Recent trends in analytical methods to determine new psychoactive substances in hair [PDF]

, 2017
New Psychoactive Substances (NPS) belong to several chemical classes, including phenethylamines, piperazines, synthetic cathinones and synthetic cannabinoids.
García Algar, Oscar, KYRIAKOU, CHRYSTALLA, MARINELLI, Enrico, Pellegrini, Manuela, ZAAMI, Simona   +4 more
core   +1 more source

Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs.

PLoS ONE, 2021
Drug-induced liver injury (DILI) is one of major causes of discontinuing drug development and withdrawing drugs from the market. In this study, we investigated chemical properties associated with DILI using in silico methods, to identify a ...
Yuki Shimizu, Takamitsu Sasaki, Jun-Ichi Takeshita, Michiko Watanabe, Ryota Shizu, Takuomi Hosaka, Kouichi Yoshinari   +6 more
doaj   +1 more source

Genetic Discrimination in the Canada and Iran's Legal System [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒Umūmī, 2018
Genetic information and the usage of this information has created profound changes in the practical application of genetics science and its function. One of these changes is "personalized medicine" in the sense of harmonizing the treatment of patients ...
vahid nazari, nahid javanmoradi
doaj   +1 more source

Trial-based Discrimination Procedure for Studying Drug Relapse in Rats

Bio-Protocol, 2019
In abstinent drug addicts, cues formerly associated with drug-taking experiences gain relapse-inducing potency (‘incubate’) over time. Animal models of incubation may help in developing treatments for relapse prevention.
Veronica Lennon, Megan Brenner, Sophia Weber, Lauren Komer, Rajtarun Madangopal   +4 more
doaj   +1 more source

Attitudes towards mental illness in Malawi: a cross-sectional survey [PDF]

, 2012
<p><b>Background:</b> Stigma and discrimination associated with mental illness are strongly linked to suffering, disability and poverty.
Chabunya, S., Crabb, J., Kokota, D., Krishnadas, R., Masson, N., Stewart, R.C.   +5 more
core   +2 more sources

Deviancy, Dependency, and Disability: The Forgotten History of Eugenics and Mass Incarceration [PDF]

, 2018
Three widely discussed explanations of the punitive carceral state are racism, harsh drug laws, and prosecutorial overreach. These three narratives, however, only partially explain how our correctional system expanded to its current overcrowded state ...
Appleman, Laura I
core   +2 more sources