Results 61 to 70 of about 34,821 (156)

Shrinkage estimation for dose-response modeling in phase II trials with multiple schedules

, 2020
Recently, phase II trials with multiple schedules (frequency of administrations) have become more popular, for instance in the development of treatments for atopic dermatitis.
Friede, Tim, Günhan, Burak Kürsad, Meyvisch, Paul   +2 more
core   +1 more source

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. [PDF]

, 1984
The human-derived promyelocytic leukemia cell line, HL-60, is known to differentiate into mature myeloid cells in the presence of 1,25-dihydroxyvitamin D3 (1,25[OH]2D3).
Donaldson, CA, Haussler, MR, Haussler, MR, Koeffler, HP, Mangelsdorf, DJ, Pike, JW   +5 more
core   +1 more source

The effect of parturient height on the median effective dose of intrathecally administered ropivacaine

Annals of Saudi Medicine, 2016
BACKGROUND: Pain during cesarean delivery is one of the more common reasons for a successful medico-legal claim. However, creating an extensive block area can result in hypotension, so determining the precise dose of local anesthetic is critical ...
Xiangdi Yu, Fangxiang Zhang
doaj   +1 more source

Phase transitions in biological membranes

, 2018
Native membranes of biological cells display melting transitions of their lipids at a temperature of 10-20 degrees below body temperature. Such transitions can be observed in various bacterial cells, in nerves, in cancer cells, but also in lung ...
A Blicher, A Blicher, A Gonzalez-Perez, A Gonzalez-Perez, A Hac, A Punnia-Moorthy, AG Lee, AL Hodgkin, AL Hodgkin, B Lautrup, D Johnston, D Papahadjopoulos, DB Mountcastle, DP Kharakoz, E London, EF DeLong, FH Johnson, FH Johnson, GH Kim, GS Manning, H Ebel, H Kamaya, H Kamaya, H Kamaya, H Träuble, HJ Galla, HM Seeger, HM Seeger, I Tasaki, J Gallaher, J Marmur, JE Rothman, JE Rothman, JLCM Vossenberg van de, JM Ritchie, JR Hazel, JR Hazel, JR Trudell, K Græsbøll, K Iwasa, K Iwasa, K Simons, KA Zecchi, KR Laub, L Onsager, LD Mosgaard, LD Mosgaard, LO Ingram, M Gudmand, M Moldovan, MC Sabra, MJ Halsey, MJ Pringle, OG Mouritsen, P Grabitz, PF Almeida, PL Privalov, R Böckmann, R Ravindra, R Winter, RS Cantor, RS Cantor, RW Glaser, S Johnson, SV Avery, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Horishita, Tian Wang, UR Pedersen, Y Kaminoh, Y Zuo   +76 more
core   +1 more source

Establishing the Median and 95% Effective Doses of Oliceridine for Immediate Post-Surgical Analgesia Following Laparoscopic Cholecystectomy: A Double-Blind, Sequential Dose-Finding Study

Drug Design, Development and Therapy
Xianghua Cao,1,2,* Huiling Xiao,1,2,* Haoran Yan,1,2,* Yujiao Wei,1,2 Qiting Wen,1,2 Zhijian Zhang,1,2 Guizhen Xu,1,2 Binbin Xu,1,2 Jian Chen,1,2 Xueping Li1,2 1Department of Anesthesiology, Dongguan Tungwah Hospital, Dongguan, People’s ...
Cao X, Xiao H, Yan H, Wei Y, Wen Q, Zhang Z, Xu G, Xu B, Chen J, Li X   +9 more
doaj  

Bioassay-guided isolation of the antioxidant constituent from Cassia alata L. leaves [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2004
Using DPPH radical scavenging assay to investigate the antioxidant activity of crude methanol extracts from the leaves, flowers and pods of Cassia alata L.
Pharkphoom Panichayupakaranant, Songsri Kaewsuwan   +1 more
doaj  

Mechanism of the age-related decrease of epinephrine-stimulated lipolysis in isolated rat adipocytes: beta-adrenergic receptor binding, adenylate cyclase activity, and cyclic AMP accumulation.

Journal of Lipid Research, 1981
beta-adrenergic binding ([3H]dihydroalprenolol), adenylate cyclase activity, and cAMP accumulation were measured in adipocytes to investigate whether the mechanism of decreased hormone-sensitive lipolytic response with age was mediated through membrane ...
E M Dax, J S Partilla, R I Gregerman
doaj   +1 more source

Effect of Dexmedetomidine on the ED50 and ED95 of Sufentanil in Patient-Controlled Intravenous Analgesia After Cesarean Section: A Randomized, Controlled, Double-Blind Trial

Drug Design, Development and Therapy
Jiabei Li,1,2 Wuchang Fu,3 Na Wang,1 Sisi Zeng,1 Xuechao Li,1 Jixiang Wan,1 Fangjun Wang1 1Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of China; 2Department of Anesthesiology, Meishan ...
Li J, Fu W, Wang N, Zeng S, Li X, Wan J, Wang F   +6 more
doaj  

Synergistic antidepressant-like effect of xylopic acid co-administered with selected antidepressants

IBRO Neuroscience Reports
Background: Xylopic acid (XA), a kaurene diterpene from the dried fruits of Xylopia aethiopica, has anxiolytic- and antidepressant-like activity in mice and zebrafish.
Charles Kwaku Benneh, Wonder Kofi Mensah Abotsi, Robert Peter Biney, Priscilla Kolibea Mante, Mustapha Kobina Abeka, Augustine Tandoh, Eric Woode   +6 more
doaj   +1 more source

Optimizing nicardipine dosage for effective control of pituitrin-induced hypertension in laparoscopic myomectomy undergoing total intravenous anesthesia

BMC Anesthesiology
Background This study aimed to determine the median effective dose (ED50) and 95% effective dose (ED95) of nicardipine for treating pituitrin-induced hypertension during laparoscopic myomectomy, providing guidance for the management of intraoperative ...
Chen Wang, Xiaoli Zhao, Yunyun Chen, Jianhua Xia, Xixue Zhang, Tingting Wang   +5 more
doaj   +1 more source