Results 61 to 70 of about 18,317 (173)

Synergistic antidepressant-like effect of xylopic acid co-administered with selected antidepressants

IBRO Neuroscience Reports
Background: Xylopic acid (XA), a kaurene diterpene from the dried fruits of Xylopia aethiopica, has anxiolytic- and antidepressant-like activity in mice and zebrafish.
Charles Kwaku Benneh, Wonder Kofi Mensah Abotsi, Robert Peter Biney, Priscilla Kolibea Mante, Mustapha Kobina Abeka, Augustine Tandoh, Eric Woode   +6 more
doaj   +1 more source

Evaluation of the antinociceptive potential of sodium valproate in mice [PDF]

Medicamentul Veterinar, 2014
Recent research in the field of algesiology demonstrated the existence of several types of pain, with complex mediation cascades. This fact prompted the use of compounds from other drug families than classical analgesics for the treatment of pain.
Lidia Cristina Chitac, Sorin Beschea, Monica Neamtu , Delia Bulea, Veronica Bild   +4 more
doaj  

Optimizing nicardipine dosage for effective control of pituitrin-induced hypertension in laparoscopic myomectomy undergoing total intravenous anesthesia

BMC Anesthesiology
Background This study aimed to determine the median effective dose (ED50) and 95% effective dose (ED95) of nicardipine for treating pituitrin-induced hypertension during laparoscopic myomectomy, providing guidance for the management of intraoperative ...
Chen Wang, Xiaoli Zhao, Yunyun Chen, Jianhua Xia, Xixue Zhang, Tingting Wang   +5 more
doaj   +1 more source

Effective Dose of Epidural Hydromorphone for Analgesia Following Caesarean Section in Using Modified Dixon Sequential Method

Journal of Pain Research
Qiao-Qiao Liu,1,* Mao Mao,1,* Ning-Hua Lin,2,* Chen-Yang Xu,1,* Qian Li,1 Chang-Shuo Jiang,1 Shan-Wu Feng,1 Hong-Mei Yuan1 1Department of Anesthesiology, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s ...
Liu QQ, Mao M, Lin NH, Xu CY, Li Q, Jiang CS, Feng SW, Yuan HM   +7 more
doaj  

The median effective dose of ciprofol combined with sufentanil in suppressing the laryngeal mask airway insertion response in both young and older adult patients

BMC Anesthesiology
Background Ciprofol, a novel intravenous anesthetic, exhibits similar sedation mechanisms and pharmacokinetic properties to propofol. However, ciprofol demonstrates greater potency and is associated with reduced injection pain compared to propofol. Given
Xuelei Zhou, Li Zhao, Wei Mao, Linlin Chen, Xianchun Liu, Linji Li   +5 more
doaj   +1 more source

ED50 of intrathecal ropivacaine for cesarean delivery with and without epidural volume extension with normal saline: a randomized controlled study.

Journal of Pain Research, 2018
M Lv,1 P Zhang,2 Z Wang3 1Department of Obestetrics and Gynecology, Affiliated Women and Children’s Hospital of Jiaxing University, Jiaxing, China; 2Department of Anesthesiology, Affiliated Women and Children’s Hospital of Jiaxing University,
Lv M, Zhang P, Wang Z
doaj  

Behavioral pharmacology of novel synthetic indazole, indole, and benzimidazole cannabinoids in rodents

Journal of Cannabis Research
Background Synthetic cannabinoids (SC) are created as alternatives to delta-9-tetrahydrocannabinol (∆9-THC) and can cause serious side effects like hallucinations and death.
Ritu A. Shetty, Rebecca D. Hill, Jared A. McDonald, Nathalie Sumien, Michael J. Forster, Michael B. Gatch   +5 more
doaj   +1 more source

In Vivo Anti-Malarial Activity of Heracleum persicum Fruit Extract, in Combination with Chloroquine against Chloroquine–Sensitive Strain of Plasmodium berghei

Iranian Journal of Public Health, 2018
Background: We evaluated the anti-malarial activity of Heracleum persicum individually and in combination with chloroquine. Methods: This study was conducted at the School of Public Health, Tehran University of Medical Sciences, Tehran, Iran in 2015 ...
Nahideh MAZHARI, Mehdi NATEGHPOUR, Peyman HEYDARIAN, Leila FARIVAR, Effat SOURI, Afsaneh MOTEVALLI HAGHI   +5 more
doaj  

The median effective dose of ciprofol combined with a low-dose sufentanil for gastroscopy in obese or nonobese patients: a dose-finding study using Dixon’s up-and-down method

Frontiers in Pharmacology
ObjectivesUnderstanding the different pharmacodynamic responses to narcotics in patients with or without obesity is particularly important for the safety of gastroscopy sedation.
Jie Zhao, Jie Zhao, Yixiao Zhang, Guowei Su, Shaoyi Wang, Xiaolin Zhang, Guoxiang Wang, Gang Chen   +7 more
doaj   +1 more source

Determination of the Median Effective Dose of Ciprofol Combined with Sufentanil in Inhibiting Tracheal Intubation Response in Female Patients

Scientific Reports
To determine the median effective dose (ED50) and the 95% effective dose (ED95) of ciprofol combined with sufentanil for inhibiting the tracheal intubation response in female patients and to evaluate the hemodynamic stability and adverse events ...
Li Zhao, Xuelei Zhou, Ting Zhang, Wei Mao, Linlin Chen, Yiping Guo, Xianchun Liu, Longyi Zhang, Linji Li   +8 more
doaj   +1 more source