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Median effective dose (ED50) of ciprofol combined with alfentanil for suppressing cervical dilation responses during hysteroscopy: a prospective Dixon up-and-down study

BMC Anesthesiology
Background Cervical dilation during hysteroscopy induces significant nociceptive stimulation that may provoke somatic response and compromise procedural conditions.
Conghui Zhang +10 more
doaj +1 more source

The 50% effective dose of hydromorphone and morphine for epidural analgesia in the hemorrhoidectomy: a double-blind, sequential dose-finding study

BMC Anesthesiology
Background Although previous studies have showed that epidural morphine can be used as a complement to local anesthetics for analgesia after postcesarean delivery under spinal anesthesia, there is little known about the analgesic dosage of epidural ...
Xianghua Cao +6 more
doaj +1 more source

Effects of voltage-gated sodium channels on the median effective dose of ropivacaine in diabetic rats

Scientific Reports
Diabetes mellitus significantly impacts perioperative anesthetic management. Patients with diabetic neuropathy exhibit increased sensitivity to local anesthetics, yet the underlying mechanisms, particularly regarding the median effective dose (ED50) of ...
Xueyin Song +8 more
doaj +1 more source

ED50 of desflurane for LMA removal: is the estimate reliable? [PDF]