Results 101 to 110 of about 10,879 (246)

Cost-effectiveness of edaravone dexborneol versus dl-3-n-butylphthalide for the treatment of acute ischemic stroke: a Chinese health care perspective

BMC Public Health
Background Edaravone dexborneol and dl-3-n-butylphthalide are two innovative brain cytoprotective drugs from China that have been approved and widely prescribed for acute ischemic stroke, and the cost of the two drugs are partially paid by the Chinese ...
Jianchun Li, Weihang Cao, Fei Zhao, Pengfei Jin   +3 more
semanticscholar   +1 more source

Edaravone for the Treatment of Motor Neurone Disease: A Critical Review of Approved and Alternative Formulations against a Proposed Quality Target Product Profile

Pharmaceutics
Edaravone is one of two main drugs for treating motor neurone disease (MND). This review proposes a specific quality target product profile (QTPP) for edaravone following an appraisal of the issues accounting for the poor clinical uptake of the approved ...
Riuna O’Neill, Okhee Yoo, Philip Burcham, Lee Yong Lim   +3 more
doaj   +1 more source

Analysis of Long‐Term Function and Survival of Edaravone Oral Suspension–Treated Patients With Amyotrophic Lateral Sclerosis Using PRO‐ACT Data as Historical Placebo Controls

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims On/Off dosing of intravenous (IV) edaravone and edaravone oral suspension was US Food and Drug Administration (FDA)‐approved for Amyotrophic Lateral Sclerosis (ALS) treatment. Placebo‐controlled trials showed that IV edaravone slows the rate of physical functional decline in patients with ALS.
Fumihiro Takahashi, Angela Genge, Manabu Hirai, Daniel Selness, Vesna Todorovic, Art Wamil, Nissim Sasson, Stephen Apple, Yoshiteru Ushirogawa   +8 more
wiley   +1 more source

Edaravone protects endotoxin-induced liver injury by inhibiting apoptosis and reducing proinflammatory cytokines

Brazilian Journal of Medical and Biological Research, 2014
Studies have shown that edaravone may prevent liver injury. This study aimed to investigate the effects of edaravone on the liver injury induced by D-galactosamine (GalN) and lipopolysaccharide (LPS) in female BALB/c mice.
L. Zong, Q.H. Yu, Y.X. Du, X.M. Deng
doaj   +1 more source

Edaravone protected human brain microvascular endothelial cells from methylglyoxal-induced injury by inhibiting AGEs/RAGE/oxidative stress. [PDF]

PLoS ONE, 2013
Subjects with diabetes experience an increased risk of cerebrovascular disease and stroke compared with nondiabetic age-matched individuals. Increased formation of reactive physiological dicarbonyl compound methylglyoxal (MGO) seems to be implicated in ...
Wenlu Li, Hongjiao Xu, Yangmin Hu, Ping He, Zhenzhen Ni, Huimin Xu, Zhongmiao Zhang, Haibin Dai   +7 more
doaj   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Cell Proliferation, EarlyView.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin, Libo Nie, Yan Deng, Ghulam Jilany Khana, Nongyue He   +4 more
wiley   +1 more source

Evaluation of the Anti-apoptotic and Anti-cytotoxic Effect of Epicatechin Gallate and Edaravone on SH-SY5Y Neuroblastoma Cells

Basic and Clinical Neuroscience, 2019
Introduction: Parkinson disease (PD) is the second most common neurodegenerative disease affecting older individuals with signs of motor disability and cognitive impairment. Epicatechin (EC) and edaravone have neuroprotective effects most probably due to
Mohammad Shokrzadeh, Hashem Javanmard, Golpar Golmohammad Zadeh, Hossein Asgarian Omran, Mona Modanlou, Saeed Yaghubi-Beklar, Ramin Ataee   +6 more
doaj  

Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse. [PDF]

PLoS ONE, 2015
Edaravone, a free radical scavenger is used widely in Japanese patients with acute cerebral infarction. This antioxidant could have therapeutic potentials for other neurological diseases.
Ken Ikeda, Yasuo Iwasaki
doaj   +1 more source

Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
Mitochondria play a critical role in aging and aging‐related diseases. This review systematically explores the mechanisms underlying mitochondrial deterioration during aging and highlights innovative therapeutic strategies for these mitochondrial problems.
Lanlan Jia, Ziyu Wei, Jinyuan Luoqian, Xi Wang, Chao Huang   +4 more
wiley   +1 more source

Synergy of combined tPA-edaravone therapy in experimental thrombotic stroke. [PDF]

PLoS ONE, 2014
Edaravone, a potent antioxidant, may improve thrombolytic therapy because it benefits ischemic stroke patients on its own and mitigates adverse effects of tissue plasminogen activator (tPA) in preclinical models.
Yu-Yo Sun, Yury M Morozov, Dianer Yang, Yikun Li, R Scott Dunn, Pasko Rakic, Pak H Chan, Koji Abe, Diana M Lindquist, Chia-Yi Kuan   +9 more
doaj   +1 more source