Effect of Edaravone Therapy on Amyotrophic Lateral Sclerosis Functional Rating Score (ALS-FRS) in Patients of Amyotrophic Lateral Sclerosis (ALS) in Central India: A Retrospective Open Label Study. [PDF]
Ann NeurosciKashyap PV +4 more
europepmc +1 more source
Concentration-Response Relationships of the Non-enzymatic Scavenging Activity of Ethyl Pyruvate Against Multiple Free Radicals. [PDF]
CureusDemura Y +5 more
europepmc +1 more source
Extract of <i>Bacopa procumbens</i> Mitigates Brain Injury and Improves Functional Outcomes Following Ischemia-Reperfusion. [PDF]
Int J Mol SciViveros-Bartolomé JM +9 more
europepmc +1 more source
Astilbin Protects Against Ischemic Stroke by Regulating ERK1/2/CREB/p90RSK Signaling and Ferroptosis-Related SLC7A11/ACSL4/GPX4 Axis: Insights from Network Pharmacology, Multi-Omics, and Molecular Dynamics. [PDF]
Int J Mol SciJin C +7 more
europepmc +1 more source
TFAM signaling molecule alleviates mitochondrial damage of cerebral ischemia-reperfusion. [PDF]
Cell Death DiscovWang W +8 more
europepmc +1 more source
Edaravone, a potent free radical scavenger, reacts with peroxynitrite to produce predominantly 4-NO-edaravone [PDF]
Redox Report, 2016 3-Methyl-1-phenyl-2-pyrazolin-5-one (edaravone) is used in clinical treatment of acute brain infarction to rescue the penumbra, based on its ability to prevent lipid peroxidation by scavenging lipid peroxyl radicals. Here, we show that edaravone also reacts with peroxynitrite to yield 4-NO-edaravone as the major product and 4-NO2-edaravone as a minor ...
Akio Fujisawa, Yorihiro Yamamoto
exaly +3 more sources
Edaravone May Prevent Ferroptosis in ALS [PDF]
Current Drug Targets, 2020 Radicava™ (Edaravone) was approved the Food and Drug Administration (FDA) as a new treatment for amyotrophic lateral sclerosis (ALS). Edaravone is a synthetic antioxidant that specifically targets oxidative damage interacting with lipid radicals in the cell.
Dusko Blagojevic +2 more
exaly +6 more sources