Results 131 to 140 of about 5,356 (175)
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Experimental Neurology, 2009
0014-4886/$ – see front matter © 2009 Elsevier Inc. Al doi:10.1016/j.expneurol.2009.03.001 ⁎ Fax: +81 75 761 9780. E-mail address: ryosuket@kuhp.kyoto-u.ac.jp. Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by progressive and relatively selective degeneration of upper and lower motor neurons.
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0014-4886/$ – see front matter © 2009 Elsevier Inc. Al doi:10.1016/j.expneurol.2009.03.001 ⁎ Fax: +81 75 761 9780. E-mail address: ryosuket@kuhp.kyoto-u.ac.jp. Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by progressive and relatively selective degeneration of upper and lower motor neurons.
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Edaravone Derivatives Containing NO-Donor Functions
Journal of Medicinal Chemistry, 2008A new series of polyvalent drugs obtained by joining edaravone with NO-donor moieties is described. All compounds display high antioxidant power together with NO-dependent vasodilator properties. The analysis of a number of molecular descriptors shows that the antioxidant activity, which is tightly linked to the presence of the edaravone substructure ...
Chegaev, Konstantin +8 more
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Edaravone for the treatment of amyotrophic lateral sclerosis
Expert Review of Neurotherapeutics, 2019Amyotrophic lateral sclerosis (ALS) is a progressive fatal disorder that affects all skeletal muscles, leading to death, mostly within 2-4 years from onset. To date, the anti-glutamatergic drug riluzole is the only drug that has been approved for the treatment of this disease; however, its efficacy is modest.
Hiide Yoshino
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International Journal of Pharmaceutics, 2009
We examined the effects of metabolic inhibitors on skin permeation of edaravone. SKF-525A, diclofenac sodium (DIC) and indomethacin (IND) were added to supernatant fluid (SF) of hairless rat (HR) skin homogenate. L-Cysteine (L-Cys) and benzotriazole (BTA), as pharmaceutical additives, were added to HR skin homogenate SF, and incubated at 37 degrees C ...
Toshiaki, Sato +2 more
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We examined the effects of metabolic inhibitors on skin permeation of edaravone. SKF-525A, diclofenac sodium (DIC) and indomethacin (IND) were added to supernatant fluid (SF) of hairless rat (HR) skin homogenate. L-Cysteine (L-Cys) and benzotriazole (BTA), as pharmaceutical additives, were added to HR skin homogenate SF, and incubated at 37 degrees C ...
Toshiaki, Sato +2 more
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Effects of edaravone on human neutrophil function
Acta Anaesthesiologica Scandinavica, 2005Background: Neutrophils play a crucial role in the antibacterial host defence system. Edaravone is used in critically ill patients who are often immuno‐compromised secondary to concomitant disease or immunosuppressive therapy. The aim of the current study was to assess the effect of edaravone, a novel free‐radical scavenger, on several aspects of ...
K, Mikawa +4 more
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Is edaravone harmful? (A placebo is not a control)
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2018Edaravone is delivered by long-term daily intravenous infusions, yet the risk of infusion was not considered in the design or analysis of studies examining the efficacy of edaravone in ALS. A reappraisal of the pivotal edaravone study (Study 19) on which claims of efficacy are based suggests that this risk cannot be dismissed, that the efficacy of ...
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Edaravone Part 2: Antibacterial Activity of Novel Substituted Azetidinone Derivatives of Edaravone
International Journal of Drug Design and DiscoveryThis paper describes development of new chemical entities of Edaravone for their antibacterial activity. The chemical name of Edaravone is 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one. Various N-(substituted benzylidenyl)-[2-(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)acetohydrazide] (4a-4e) and 2-(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)
R.V. Antre +3 more
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