Results 121 to 130 of about 10,879 (246)

Free radical scavenger, edaravone, reduces the lesion size of lacunar infarction in human brain ischemic stroke

BMC Neurology, 2011
Background Although free radicals have been reported to play a role in the expansion of ischemic brain lesions, the effect of free radical scavengers is still under debate.
Suzuki Akifumi, Yoshioka Shotaroh, Nakase Taizen   +2 more
doaj   +1 more source

Astrocytes Contribute to Motor Neuron Degeneration in ALS via the TRAIL‐DR5 Signaling Pathway

Journal of Neurochemistry, Volume 169, Issue 7, July 2025.
Schematic diagram of astrocytes inducing motor neuron damage through the TRAIL‐DR5 pathway. In ALS, astrocytes induce motor neuron death through the secretion of TRAIL. TRAIL binds to death receptor 5 (DR5) on motor neurons, leading to the upregulation of genes associated with oxidative stress, apoptosis, pyroptosis, and necroptosis.
Kangqin Yang, Yang Liu, Wenhua Deng, Zhenxiang Gong, Lifang Huang, Zehui Li, Min Zhang   +6 more
wiley   +1 more source

Safety and efficacy of Edaravone Dexborneol versus edaravone for patients with acute ischaemic stroke: a phase II, multicentre, randomised, double-blind, multiple-dose, active-controlled clinical trial

Stroke and Vascular Neurology, 2019
Background Edaravone Dexborneol is a novel neuroprotective agent that comprised edaravone and (+)-borneol, a food additive with an anti-inflammatory effect in animal ischaemic stroke models.
Yongjun Wang, Yilong Wang, Xingquan Zhao, Huisheng Chen, Jie Xu, Anxin Wang, Zhiqiang Gao, Xiaoping Gao, Junshan Zhou   +8 more
doaj   +1 more source

The Effect of Edaravone on Amyotrophic Lateral Sclerosis

Journal of Neurology Research, 2020
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease, is fatal within 3 years of symptom onset. Both upper motor neurons and lower motor neurons are targeted. It is hypothesized that: edaravone is effective at managing ALS. This review article used a combination of secondary and primary research articles to gain a plethora of information to
openaire   +2 more sources

The Novel Antioxidant Edaravone: From Bench to Bedside

Cardiovascular Therapeutics, 2008
Over the last decade, important advances have been made to support the fact that reactive oxygen species (ROS) are generated and play a harmful role during the acute and late stages of cerebral ischemia. Several drugs, such as radical scavengers and antioxidants, have been evaluated in preclinical and clinical studies.
Munenori Tahara, Toshiaki Watanabe, Satoru Todo   +2 more
openaire   +3 more sources

Edaravone exerts brain protective function by reducing the expression of AQP4, APP and Aβ proteins

Open Life Sciences, 2019
This study aims to investigate the changes of aquaporin-4 (AQP4), β-amyloid precursor proteins (APP) and β-amyloid (Aβ) in brain tissues after cerebral ischemiareperfusion injury (CIRI), and evaluate the effect of edaravone.
Ren Haiyan, Ma Lijuan, Gong Xueli, Xu Chenbo, Zhang Yuge, Ma Meilei, Watanabe Kenichi, Wen Juan   +7 more
doaj   +1 more source

Edaravone scavenges nitric oxide [PDF]

, 2002

openalex   +1 more source

Structure–activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone) [PDF]

, 2003
Kazutoshi Watanabe, Yasuhiro Morinaka, Katsuhiko Iseki, Toshiaki Watanabe, Satoshi Yuki, Hiroyoshi Nishi   +5 more
openalex   +1 more source

A Free Radical Scavenger, Edaravone, Attenuates Steatosis and Cell Death via Reducing Inflammatory Cytokine Production in Rat Acute Liver Injury [PDF]

, 2003
Nobuhiro Nakamoto, Shinichiro Tada, Kaori Kameyama, Kumi Kitamura, Satoshi Kurita, Yoshimasa Saito, Hidetsugu Saito, Hiromasa Ishii   +7 more
openalex   +1 more source

In Vivo Radioprotection of Mice by 3-Methyl-1-phenyl-2-pyrazolin-5-one (Edaravone; Radicut®), a Clinical Drug [PDF]

, 2004
Kazunori Anzai, Masako Furuse, Akira Yoshida, Azusa Matsuyama, Takashi Moritake, Koji Tsuboi, Nobuo Ikota   +6 more
openalex   +1 more source