Results 221 to 230 of about 33,099 (254)

Evidence for adjuvanticity of anthrax edema toxin

Vaccine, 2006
Bacillus anthracis edema factor (EF) is an adenylate cyclase that increases intracellular cAMP concentrations. Since EF is present as a contaminant in the licensed protective antigen(PA)-based vaccines, we investigated its effect on anti-PA humoral immune response in BALB/c mice.
Anne, Quesnel-Hellmann, Aurélie, Cleret, Dominique R, Vidal, Jean-Nicolas, Tournier   +3 more
openaire   +2 more sources

Inhibition of platelet aggregation by anthrax edema toxin

Biochemical and Biophysical Research Communications, 2006
Edema toxin is a key virulence determinant in anthrax pathogenesis that causes augmentation of cAMP inside host cells. This exotoxin has been implicated in facilitating bacterial invasion by impairing host defenses. Here, we report for the first time that edema toxin plays an important role in suppression of platelet aggregation; an effect that could ...
Sheeba, Alam, Megha, Gupta, Rakesh, Bhatnagar   +2 more
openaire   +2 more sources

Modeling the Carbohydrate-Binding Specificity of Pig Edema Toxin

Biochemistry, 1998
The wild-type binding pentamer of Shiga-like toxin IIe (SLT-IIe) binds both the globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) cell surface glycolipids, whereas the double mutant GT3 (Q65E/K67Q) exhibits a marked preference for Gb3 [Tyrrell, G. J., et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 524-528].
M D, Cummings, H, Ling, G D, Armstrong, J L, Brunton, R J, Read   +4 more
openaire   +2 more sources

Pertussis Toxin–Induced Lung Edema

American Journal of Respiratory Cell and Molecular Biology, 1999
The mechanism by which pertussis toxin (Ptx) causes lung edema is not clear. We investigated the role of pulmonary manganese superoxide dismutase (MnSOD) and protein kinase C (PKC) in Ptx-induced lung edema. We demonstrated that intraperitoneal injection of Ptx at a concentration of 5 microg/100 g body weight caused a similar degree of lung edema in 2 ...
M F, Tsan, X, Cao, J E, White, J, Sacco, C Y, Lee   +4 more
openaire   +2 more sources

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction

Frontiers in Bioscience, 2007
Fatalities due to anthrax are associated with severe hypotension suggesting that the toxins generated from Bacillus anthracis, lethal toxin (LeTx) and edema toxin (EdTx), have cardiovascular effects. Here, we demonstrate the effects of these toxins and characterize their effects by echocardiography.
Linley E, Watson, Jonathan, Mock, Hind, Lal, Guangrong, Lu, Raymond W, Bourdeau, Wei-Jen, Tang, Stephen H, Leppla, David E, Dostal, Arthur E, Frankel   +8 more
openaire   +2 more sources

Murine macrophage transcriptional and functional responses to Bacillus anthracis edema toxin

Microbial Pathogenesis, 2006
Edema toxin (EdTx), which is a combination of edema factor and a binding moiety (protective antigen), is produced by Bacillus anthracis, the etiological agent of anthrax. EdTx is an adenylyl cyclase enzyme that converts adenosine triphosphate to adenosine-3',5'-monophosphate, resulting in interstitial edema seen in anthrax patients.
Jason E, Comer, Cristi L, Galindo, Fan, Zhang, Autumn M, Wenglikowski, Katie L, Bush, Harold R, Garner, Johnny W, Peterson, Ashok K, Chopra   +7 more
openaire   +2 more sources

[Nonhemodynamic pulmonary edema due to toxins].

Annales de l'anesthesiologie francaise, 1976
Lesional pulmonary edema caused by substances which are directly caustic for the gastrointestinal pathways (strong acids and bases, inhaled vomit) are opposed by their immediate and long-term gravity with those due to cardiotropic medicamentatous toxins or volemic overloading which lead to curable pulmonary edema.
J P, Frejaville, Y, Tourtier, J, Susini, A, De Courcy   +3 more
openaire   +1 more source

Overview of the role of Shiga toxins in porcine edema disease pathogenesis

Toxicon, 2018
Shiga toxin-producing Escherichia coli (STEC) have been implicated as the cause of enterotoxemias, such as hemolytic uremic syndrome in humans and edema disease (ED) of pigs. Stx1 and Stx2 are the most common types found in association with illness, but only Stx2e is associated with disease in the animal host.
Casanova, Natalia Andrea, Redondo, Leandro Martin, Dailoff, Gabriela Cecilia, Arenas, David, Fernandez Miyakawa, Mariano Enrique   +4 more
openaire   +3 more sources

Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage

Microbial Pathogenesis, 2008
Bacillus anthracis infections are frequently associated with severe and often irreversible hypotensive shock despite appropriate antibiotics and aggressive hemodynamic and pulmonary support. Based on the observations that the anthrax secreted proteins-protective antigen (PA), lethal factor (LF), and edema factor (EF) also produce shock and mortality in
Shu-Ru, Kuo, Mark C, Willingham, Sarah H, Bour, Elissa A, Andreas, Seong Kyu, Park, Carney, Jackson, Nicholas S, Duesbery, Stephen H, Leppla, Wei-Jen, Tang, Arthur E, Frankel   +9 more
openaire   +2 more sources