Results 61 to 70 of about 36,103 (144)
Both lethal and edema toxins of Bacillus anthracis disrupt the human dendritic cell chemokine network. [PDF]
PLoS ONE, 2012 Bacillus anthracis, the agent of anthrax, produces two main virulence factors: a capsule and two toxins. Both lethal toxin (LT) and edema toxin (ET) paralyze the immune defense system.
Aurélie Cleret-Buhot +3 more
doaj +1 more source
Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells
Toxins, 2018 Pulmonary permeability edema is characterized by reduced alveolar Na+ uptake capacity and capillary barrier dysfunction and is a potentially lethal complication of listeriosis.
Guang Yang +14 more
doaj +1 more source
Diminished but Not Abolished Effect of Two His351 Mutants of Anthrax Edema Factor in a Murine Model
Toxins, 2016 Edema toxin (ET), which is composed of a potent adenylate cyclase (AC), edema factor (EF), and protective antigen (PA), is one of the major toxicity factors of Bacillus anthracis.
Taoran Zhao +10 more
doaj +1 more source
Anthrax Edema Toxin Modulates PKA- and CREB-Dependent Signaling in Two Phases
PLoS ONE, 2008 Anthrax edema toxin (EdTx) is an adenylate cyclase which operates in the perinuclear region of host cells. However, the action of EdTx is poorly understood, especially at molecular level. The ability of EdTx to modulate cAMP-dependent signaling was studied in Jurkat T cells and was compared with that of other cAMP-rising agents: Bordetella pertussis ...
Andrea, Puhar +5 more
openaire +5 more sources
Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin
Toxins, 2010 Anthrax is caused by the gram-positive bacterium Bacillus anthracis. The pathogenesis of this disease is dependent on the presence of two binary toxins, edema toxin (EdTx) and lethal toxin (LeTx). LeTx, the major virulence factor contributing to anthrax,
Jennifer Bromberg-White +2 more
doaj +1 more source
BMC Biotechnology, 2011 Background Anthrax is caused by the bacterium Bacillus anthracis and is regarded as one of the most prominent bioterrorism threats. Anthrax toxicity is induced by the tripartite toxin complex, composed of the receptor-binding anthrax protective antigen ...
Andersen Kasper +4 more
doaj +1 more source
Toxins, 2015 Bacillus anthracis adenylyl cyclase toxin edema factor (EF) is one component of the anthrax toxin and is essential for establishing anthrax disease. EF activation by the eukaryotic Ca2+-sensor calmodulin (CaM) leads to massive cAMP production resulting ...
Carolin Lübker +6 more
doaj +1 more source
Nonallergic Eyelid Edema After Botulinum Toxin Type A Injection
Medicine, 2015 Periocular botulinum toxin type A (BoNTA) injections are generally safe. Ptosis is the most common adverse effect, whereas eyelid edema is rarely reported. There is no consensus on the latter's incidence, clinical course, or treatment strategy. Here we managed a 59-year-old woman who received BoNTA injections to her forehead, glabella, and eye corner ...
Chang, Yin-Shuo +4 more
openaire +2 more sources
Activity of the
BMC Infectious Diseases, 2008 Background Anthrax is caused by Bacillus anthracis that produce two exotoxins, lethal toxin and edema toxin. The lethal toxin is composed of the lethal factor (LF) complexed with the cell binding protective antigen (PA83, 83 kDa).
Jett Marti +4 more
doaj +1 more source
The FASEB Journal, 2008 Our separate studies have shown that nasal co‐administration of anthrax edema toxin (EdTx) derivative [i.e., protective antigen (PA) plus edema factor (EF) mutant N447S], enhances mucosal IgA and systemic immunity to both PA and co‐administered unrelated protein antigen.
Prosper N Boyaka +3 more
openaire +1 more source