Results 41 to 50 of about 36,103 (144)
Pathogens, 2022 Anthrax has been feared for its high mortality in animals and humans for centuries. The etiologic agent is considered a potentially devastating bioweapon, and since 1876―when Robert Koch demonstrated that Bacillus anthracis caused anthrax―it has been ...
William A. Bower +6 more
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Expression of either Lethal Toxin or Edema Toxin by Bacillus anthracis Is Sufficient for Virulence in a Rabbit Model of Inhalational Anthrax [PDF]
Infection and Immunity, 2012 ABSTRACT The development of therapeutics against biothreats requires that we understand the pathogenesis of the disease in relevant animal models. The rabbit model of inhalational anthrax is an important tool in the assessment of potential therapeutics against Bacillus anthracis . We investigated the roles
Julie A, Lovchik +4 more
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Journal of Biomedical Science, 2019 Background Shiga toxin 2 from enterohemorrhagic Escherichia coli is the etiologic agent of bloody diarrhea, hemolytic uremic syndrome and derived encephalopathies that may result to death in patients.
Clara Berdasco +7 more
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Scientific Reports, 2021 Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, into the cell ...
Alexandra J. Machen +2 more
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ToxinsBacillus anthracis has three main virulence factors: an extracellular capsule and two binary toxins (lethal toxin—consists of a lethal factor and a protective antigen, and edema toxin—consists of an edema factor and a protective antigen).
Olga V. Kalmantaeva +7 more
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Rapidly improving acute myocarditis after a scorpion sting
Türk Kardiyoloji Derneği Arşivi, 2013 Scorpion stings are usually benign, but especially cardiovascular death has been reported due to complications. Local reactions at the site of the sting as well as organ dysfunction may be due to the effects of a systemic toxin.
Nermin Bayar +3 more
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Tumor endothelium marker-8 based decoys exhibit superiority over capillary morphogenesis protein-2 based decoys as anthrax toxin inhibitors. [PDF]
PLoS ONE, 2011 Anthrax toxin is the major virulence factor produced by Bacillus anthracis. The toxin consists of three protein subunits: protective antigen (PA), lethal factor, and edema factor.
Chenguang Cai +8 more
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Anthrax Lethal Toxin-Induced Gene Expression Changes in Mouse Lung
Toxins, 2011 A major virulence factor of Bacillus anthracis is the anthrax Lethal Toxin (LeTx), a bipartite toxin composed of Protective Antigen and Lethal Factor. Systemic administration of LeTx to laboratory animals leads to death associated with vascular leakage ...
A. Darise Farris +8 more
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Anthrax Lethal and Edema Toxins Fail to Directly Impair Human Platelet Function [PDF]
The Journal of Infectious Diseases, 2011 Hemorrhage is a prominent clinical manifestation of systemic anthrax. Therefore, we have examined the effects of anthrax lethal and edema toxins on human platelets. We find that anthrax lethal toxin fails to cleave its target, mitogen-activated protein kinase 1, and anthrax edema toxin fails to increase intracellular cyclic adenosine monophosphate ...
Kassidy M, Chauncey +4 more
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Tumor Targeting and Drug Delivery by Anthrax Toxin
Toxins, 2016 Anthrax toxin is a potent tripartite protein toxin from Bacillus anthracis. It is one of the two virulence factors and causes the disease anthrax.
Christopher Bachran, Stephen H. Leppla
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