Results 21 to 30 of about 36,103 (144)

Corneal edema due to botanical toxins

IP International Journal of Ocular Oncology and Oculoplasty, 2020
Corneal edema following contact with plant extracts occur not only with horticultural workers but also with amateur gardeners. The condition causes reasonable visual debility but is reversible and self limiting. Till date, no established therapeutic protocol exists for management of this particular condition.To re-examine the etiological factors behind
Soumen Chakraborty, Ratandep Kumar Agrawalla   +1 more
openaire   +1 more source

T Cell Targeting by Anthrax Toxins: Two Faces of the Same Coin

Toxins, 2011
Bacillus anthracis, similar to other bacterial pathogens, has evolved effective immune evasion strategies to prolong its survival in the host, thus ensuring the unchecked spread of the infection.
Silvia Rossi Paccani, Cosima T. Baldari
doaj   +1 more source

Transcriptional stimulation of anthrax toxin receptors by anthrax edema toxin and Bacillus anthracis Sterne spore [PDF]

Microbial Pathogenesis, 2007
We used quantitative real-time RT-PCR to not only investigate the mRNA levels of anthrax toxin receptor 1 (ANTXR1) and 2 (ANTXR2) in the murine J774A.1 macrophage cells and different tissues of mice, but also evaluate the effect of anthrax edema toxin and Bacillus anthracis Sterne spores on the expression of mRNA of these receptors.
Qingfu, Xu, Eric D, Hesek, Mingtao, Zeng
openaire   +2 more sources

Globotetraosylceramide Is Recognized by the Pig Edema Disease Toxin

Journal of Biological Chemistry, 1989
The pig edema disease toxin has been shown by a tlc glycolipid binding assay to bind specifically to globotetraosylceramide (Gb4, GalNAc beta 1-3Gal alpha 1-4Gal beta 1-4GlcCer.). Binding was reduced for globotriosylceramide (Gb3, Gal alpha 1-4Gal beta 1-4GlcCer) and more markedly for the Forssman antigen (GalNAc alpha 1-3GalNAc beta 1-3Gal alpha 1 ...
S, DeGrandis, H, Law, J, Brunton, C, Gyles, C A, Lingwood   +4 more
openaire   +2 more sources

Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding [PDF]

Proceedings of the National Academy of Sciences, 2009
This study describes the isolation and characterization of a neutralizing monoclonal antibody (mAb) against anthrax edema factor, EF13D. EF13D neutralized edema toxin (ET)-mediated cyclic AMP (cAMP) responses in cells and protected mice from both ET-induced footpad edema and systemic ET-mediated lethality.
Zhaochun, Chen, Mahtab, Moayeri, Huaying, Zhao, Devorah, Crown, Stephen H, Leppla, Robert H, Purcell   +5 more
openaire   +2 more sources

Recombinant Production and Characterization of a New Toxin from Cryptops iheringi Centipede Venom Revealed by Proteome and Transcriptome Analysis

Toxins, 2021
Among the Chilopoda class of centipede, the Cryptops genus is one of the most associated with envenomation in humans in the metropolitan region of the state of São Paulo. To date, there is no study in the literature about the toxins present in its venom.
Lhiri Hanna De Lucca Caetano, Milton Yutaka Nishiyama-Jr, Bianca de Carvalho Lins Fernandes Távora, Ursula Castro de Oliveira, Inácio de Loiola Meirelles Junqueira-de-Azevedo, Eliana L. Faquim-Mauro, Geraldo Santana Magalhães   +6 more
doaj   +1 more source

On some toxinological aspects of the starfish Stellaster equestris (Retzius, 1805)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2008
Whole-body extracts in methanol were obtained from the starfish Stellaster equestris. The crude toxin was fractionated stepwise using diethylaminoethyl (DEAE) cellulose column chromatography.
U Kanagarajan, S Bragadeeswaran, K Venkateshvaran   +2 more
doaj   +1 more source

LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. [PDF]

PLoS Pathogens, 2007
Anthrax toxin (AnTx) plays a key role in the pathogenesis of anthrax. AnTx is composed of three proteins: protective antigen (PA), edema factor, and lethal factor (LF). PA is not toxic but serves to bind cells and translocate the toxic edema factor or LF
John J Young, Jennifer L Bromberg-White, Cassandra Zylstra, Joseph T Church, Elissa Boguslawski, James H Resau, Bart O Williams, Nicholas S Duesbery, Nicholas S Duesbery   +8 more
doaj   +1 more source

Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling

Toxins, 2019
Myeloid phagocytes have evolved to rapidly recognize invading pathogens and clear them through opsonophagocytic killing. The adenylate cyclase toxin (CyaA) of Bordetella pertussis and the edema toxin (ET) of Bacillus anthracis are both calmodulin ...
Shakir Hasan, Waheed Ur Rahman, Peter Sebo, Radim Osicka   +3 more
doaj   +1 more source

Innate Immune Interactions between Bacillus anthracis and Host Neutrophils

Frontiers in Cellular and Infection Microbiology, 2018
Bacillus anthracis, the causative agent of anthrax, has been a focus of study in host-pathogen dynamics since the nineteenth century. While the interaction between anthrax and host macrophages has been extensively modeled, comparatively little is known ...
Janet Z. Liu, Syed R. Ali, Ethan Bier, Victor Nizet, Victor Nizet   +4 more
doaj   +1 more source