Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages. [PDF]
PLoS Pathogens, 2007 Bacillus anthracis, the etiological agent of anthrax, is a spore-forming gram-positive bacterium. Infection with this pathogen results in multisystem dysfunction and death. The pathogenicity of B.
Benoit Raymond +7 more
doaj +4 more sources
Anthrax edema toxin impairs clearance in mice. [PDF]
Infect Immun, 2012 ABSTRACT The anthrax edema toxin (ET) of Bacillus anthracis is composed of the receptor-binding component protective antigen (PA) and of the adenylyl cyclase catalytic moiety, edema factor (EF). Uptake of ET into cells raises intracellular concentrations of the secondary messenger cyclic AMP, thereby ...
Sastalla I +7 more
europepmc +4 more sources
Contribution of Lethal Toxin and Edema Toxin to the Pathogenesis of Anthrax Meningitis [PDF]
Infection and Immunity, 2011 ABSTRACT Bacillus anthracis is a Gram-positive spore-forming bacterium that causes anthrax disease in humans and animals. Systemic infection is characterized by septicemia, toxemia, and meningitis, the main neurological complication associated with high mortality. We have shown previously that B. anthracis
Celia M, Ebrahimi +4 more
openaire +2 more sources
Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin. [PDF]
Biochemistry, 2019 Anthrax, a lethal, weaponizable disease caused by Bacillus anthracis, acts through exotoxins that are primary mediators of systemic toxicity and also targets for neutralization by passive immunotherapy. The ease of engineering B. anthracis strains resistant to established therapy and the historic use of the microbe in bioterrorism present a compelling ...
Farcasanu M +8 more
europepmc +4 more sources
Structure-based redesign of an edema toxin inhibitor [PDF]
Bioorganic & Medicinal Chemistry, 2012 Edema factor (EF) toxin of Bacillus anthracis (NIAID category A), and several other toxins from NIAID category B Biodefense target bacteria are adenylyl cyclases or adenylyl cyclase agonists that catalyze the conversion of ATP to 3',5'-cyclic adenosine monophosphate (cAMP).
Deliang, Chen +9 more
openaire +2 more sources
Anthrax Edema Toxin Sensitizes DBA/2J Mice to Lethal Toxin [PDF]
Infection and Immunity, 2007 ABSTRACT Anthrax toxin is made up of three separate protein components: the receptor-binding protective antigen (PA), the adenylyl cyclase edema factor (EF), and the metalloproteinase lethal factor (LF). EF and PA constitute edema toxin (ET), which causes edema when injected subcutaneously.
Aaron M, Firoved +5 more
openaire +2 more sources
Correlation between in vitro cytotoxicity and in vivo lethal activity in mice of epsilon toxin mutants from Clostridium perfringens. [PDF]
PLoS ONE, 2014 Epsilon toxin (Etx) from Clostridium perfringens is a pore-forming protein with a lethal effect on livestock, producing severe enterotoxemia characterized by general edema and neurological alterations.
Jonatan Dorca-Arévalo +5 more
doaj +1 more source
Anthrax Edema Toxin Cooperates with Lethal Toxin to Impair Cytokine Secretion during Infection of Dendritic Cells [PDF]
The Journal of Immunology, 2005 Abstract Bacillus anthracis secretes two critical virulence factors, lethal toxin (LT) and edema toxin (ET). In this study, we show that murine bone marrow-derived dendritic cells (DC) infected with B. anthracis strains secreting ET exhibit a very different cytokine secretion pattern than DC infected with B.
Tournier, Jean-Nicolas +7 more
openaire +4 more sources
Contributions of Histamine, Prostanoids, and Neurokinins to Edema Elicited by Edema Toxin fromBacillus anthracis [PDF]
Infection and Immunity, 2007 ABSTRACTBacillus anthracisedema toxin (ET), composed of protective antigen and an adenylate cyclase edema factor (EF), elicits edema in host tissues, but the target cells and events leading from EF-mediated cyclic-AMP production to edema are unknown.
Jeffrey, Tessier +6 more
openaire +2 more sources
Cellular and physiological effects of anthrax exotoxin and its relevance to disease
Frontiers in Cellular and Infection Microbiology, 2012 Bacillus anthracis, the causative agent of anthrax, secretes a tripartite exotoxin that exerts pleiotropic effects on the host. The purification of the exotoxin components, protective antigen, lethal factor, and edema factor allowed the rapid ...
David Edward Lowe, Ian Justin Glomski
doaj +1 more source