Results 31 to 40 of about 36,103 (144)

Comprehensive characterization of toxins during progression of inhalation anthrax in a non-human primate model.

PLoS Pathogens, 2022
Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive, and late-fulminant. We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edema ...
Anne E Boyer, Maribel Gallegos-Candela, Renato C Lins, Maria I Solano, Adrian R Woolfitt, John S Lee, Daniel C Sanford, Katherine A B Knostman, Conrad P Quinn, Alex R Hoffmaster, James L Pirkle, John R Barr   +11 more
doaj   +1 more source

Heat-Labile Toxin from Enterotoxigenic Escherichia coli Causes Systemic Impairment in Zebrafish Model

Toxins, 2021
Heat-labile toxin I (LT-I), produced by strains of enterotoxigenic Escherichia coli (ETEC), causes profuse watery diarrhea in humans. Different in vitro and in vivo models have already elucidated the mechanism of action of this toxin; however, their use ...
Camila Henrique, Maria Alice Pimentel Falcão, Luciana De Araújo Pimenta, Adolfo Luís Almeida Maleski, Carla Lima, Thais Mitsunari, Sandra Coccuzzo Sampaio, Mônica Lopes-Ferreira, Roxane Maria Fontes Piazza   +8 more
doaj   +1 more source

Neutralizing Monoclonal Antibody to Edema Toxin and Its Effect on Murine Anthrax [PDF]

Infection and Immunity, 2010
ABSTRACTEdema factor (EF) is a component of an anthrax toxin that functions as an adenylate cyclase. Numerous monoclonal antibodies (MAbs) have been reported for the otherBacillus anthracistoxin components, but relatively few to EF have been studied. We report the generation of six murine hybridoma lines producing two IgM and four IgG1 MAbs to EF.
Lisa, Winterroth, Johanna, Rivera, Antonio S, Nakouzi, Ekaterina, Dadachova, Arturo, Casadevall   +4 more
openaire   +2 more sources

Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism.

PLoS ONE, 2010
BackgroundAnthrax toxin is comprised of protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins are individually nontoxic; however, when PA assembles with LF and EF, it produces lethal toxin and edema toxin, respectively ...
Alexander F Kintzer, Harry J Sterling, Iok I Tang, Evan R Williams, Bryan A Krantz   +4 more
doaj   +1 more source

Quantitative Mass Spectrometry for Bacterial Protein Toxins — A Sensitive, Specific, High-Throughput Tool for Detection and Diagnosis

Molecules, 2011
Matrix-assisted laser-desorption time-of-flight (MALDI-TOF) mass spectrometry (MS) is a valuable high-throughput tool for peptide analysis. Liquid chromatography electrospray ionization (LC-ESI) tandem-MS provides sensitive and specific quantification of
Suzanne Kalb, Conrad P. Quinn, John R. Barr, Hercules Moura, Renato C. Lins, Zsuzsanna Kuklenyik, Adrian Woolfitt, Maribel Gallegos-Candela, Anne E. Boyer   +8 more
doaj   +1 more source

Contributions of Edema Factor and Protective Antigen to the Induction of Protective Immunity by Bacillus anthracis Edema Toxin as an Intranasal Adjuvant [PDF]

The Journal of Immunology, 2010
Abstract We have shown that intranasal coapplication of Bacillus anthracis protective Ag (PA) together with a B. anthracis edema factor (EF) mutant having reduced adenylate cyclase activity (i.e., EF-S414N) enhances anti-PA Ab responses, but also acts as a mucosal adjuvant for coadministered unrelated Ags.
Duverger, Alexandra, Carre, Jeanne-Marie, Jee, Junbae, Leepla, Stephen, H., Cormet-Boyaka, Estelle, Tang, Wei-Jen, Tomé, Daniel, Boyaka, Prosper, N.   +7 more
openaire   +4 more sources

The Potential Pathogenic Contributions of Endothelial Barrier and Arterial Contractile Dysfunction to Shock Due to B. anthracis Lethal and Edema Toxins

Toxins, 2017
Shock with B. anthracis infection is particularly resistant to conventional cardiovascular support and its mortality rate appears higher than with more common bacterial pathogens.
Dante A. Suffredini, Xizhong Cui, Wanying Xu, Yan Li, Peter Q. Eichacker   +4 more
doaj   +1 more source

Lung endothelial cells are sensitive to epsilon toxin from Clostridium perfringens

Veterinary Research, 2020
The pore-forming protein epsilon toxin (Etx) from Clostridium perfringens produces acute perivascular edema affecting several organs, especially the brain and lungs.
Jonatan Dorca-Arévalo, Eduard Dorca, Benjamín Torrejón-Escribano, Marta Blanch, Mireia Martín-Satué, Juan Blasi   +5 more
doaj   +1 more source

A Review of the Efficacy of FDA-Approved B. anthracis Anti-Toxin Agents When Combined with Antibiotic or Hemodynamic Support in Infection- or Toxin-Challenged Preclinical Models

Toxins, 2021
Anti-toxin agents for severe B. anthracis infection will only be effective if they add to the benefit of the two mainstays of septic shock management, antibiotic therapy and titrated hemodynamic support.
Zoe Couse, Xizhong Cui, Yan Li, Mahtab Moayeri, Stephen Leppla, Peter Q. Eichacker   +5 more
doaj   +1 more source

Cytoskeleton as an Emerging Target of Anthrax Toxins

Toxins, 2012
Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET).
Jean-Nicolas Tournier, Yannick Trescos
doaj   +1 more source