Results 31 to 40 of about 4,089 (153)

Association between plasma p‐tau181 levels and the evolution of cognitive and physical performance in a cohort of cognitively impaired older adults with frailty criteria: Longitudinal data from the CogFrail study

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, -Not available-.
Abstract INTRODUCTION Evidence linking plasma phosphorylated tau (p‐tau)181 to cognitive decline comes from studies conducted in younger, selected research populations, raising questions about the generalizability of these findings to older adults meeting frailty criteria.
Davide Angioni, Julien Delrieu, Christelle Cantet, Gaelle Soriano, Federico Bellelli, Bruno Vellas, Sandrine Andrieu, Sandrine Sourdet   +7 more
wiley   +1 more source

Use of theophylline in the investigation of pseudothrombocytopenia induced by edetic acid (EDTA-2K). [PDF]

Journal of Clinical Pathology, 1988
In automated cell counting of edetic acid (EDTA-2K) anticoagulated blood, thrombocytopenia is occasionally seen which bears no relation to any underlying disease. In this study a heparin and soluble theophylline mixture was used to measure accurately platelet numbers in patients with such pseudothrombocytopenia.
O, Ohnuma, Y, Shirata, K, Miyazawa
openaire   +2 more sources

Removal of Toxic Metabolites—Chelation: Manganese Disorders

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Manganese (Mn) overload is a characteristic of multiple disease entities, from acquired manganism upon environmental or occupational overexposure, to end‐stage liver disease and certain genetic disorders. The latter include hypermanganesaemia with dystonia 1 and 2 caused by pathogenic variants in the genes encoding the Mn transporters SLC30A10
Hendrik Vogt, George E. Kostakis, Rupert Purchase, John Spencer, Karin Tuschl   +4 more
wiley   +1 more source

Endoplasmic reticulum stress induces spatial memory deficits by activating GSK‐3

Journal of Cellular and Molecular Medicine, Volume 22, Issue 7, Page 3489-3502, July 2018., 2018
Abstract Endoplasmic reticulum (ER) stress is involved in Alzheimer's disease (AD), but the mechanism is not fully understood. Here, we injected tunicamycin (TM), a recognized ER stress inducer, into the brain ventricle of Sprague‐Dawley (SD) rats to induce the unfolded protein response (UPR), demonstrated by the enhanced phosphorylation of pancreatic ...
Li Lin, Jie Cao, Shu‐Sheng Yang, Zheng‐Qi Fu, Peng Zeng, Jiang Chu, Lin‐Na Ning, Teng Zhang, Yan Shi, Qing Tian, Xin‐Wen Zhou, Jian‐Zhi Wang   +11 more
wiley   +1 more source

Phosphate in Physiological and Pathological Mineralization: Important yet Often Unheeded

MedComm, Volume 6, Issue 7, July 2025.
Phosphate serves as a building block for physiological mineralization, and as a signaling molecule that regulates the activity of mineralizing cells. The disturbance in these processes could induce a series of pathological mineralization, with abnormal mineralization of hard tissues and ectopic mineralization of soft tissues being the most ...
Wen Qin, San‐yang Yu, Jia‐lu Gao, Jian‐fei Yan, Qian‐qian Wan, Shuai‐lin Jia, Franklin Tay, Kai Jiao, Lina Niu   +8 more
wiley   +1 more source

Evaluation of Anti‐Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa

Oxidative Medicine and Cellular Longevity, Volume 2017, Issue 1, 2017., 2017
Inflammation is the major causative factor of different diseases such as cardiovascular disease, diabetes, obesity, osteoporosis, rheumatoid arthritis, inflammatory bowel disease, and cancer. Anti‐inflammatory drugs are often the first step of treatment in many of these diseases. The present study is aimed at evaluating the anti‐inflammatory properties
Kotha Anilkumar, Gorla V. Reddy, Rajaram Azad, Nagendra Sastry Yarla, Gangappa Dharmapuri, Anand Srivastava, Mohammad A. Kamal, Reddanna Pallu, Ilaria Peluso   +8 more
wiley   +1 more source

In vitro analysis of two irrigation activation systems for cleaning mesial canals in lower molars

Revista Facultad de Odontología Universidad de Antioquia
Introduction: this study aimed to compare the efficacy of two different endodontic activation systems in removing debris from the mesial canals of mandibular molars across root thirds.
Allison Gálvez-Saavedra, Guadalupe Lavalle-Vidal, Gabriel Nima   +2 more
doaj   +1 more source

Cell‐Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Li et al. defined two novel glutamatergic neuronal subtypes in the medial mammillary nucleus, pars lateralis‐located parvalbumin (PV) neurons, and basalis‐located Drd2 neurons. PV and Drd2 neurons differ in their electrophysiological properties encoded by Kcnn4 and Cacna1h, and selectively modulate place and object recognition memory by two distinct ...
Lanfang Li, Yiqing Guo, Wei Jing, Xiaomei Tang, Jinyu Zeng, Zhenye Hou, Yige Song, Aodi He, Hao Li, Ling‐Qiang Zhu, Youming Lu, Xinyan Li   +11 more
wiley   +1 more source

A comparative study of edetate calcium disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults [PDF]

Clinical Toxicology, 2018
We evaluated the efficacy of two antidotes, edetate calcium disodium (CaNa2EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults.Thirty-seven patients with blood lead concentrations >40 μg/dL and positive CaNa2EDTA lead mobilization were randomized to receive 1050 mg/m2/day of oral DMSA (n = 21) or 500 mg/m2/day of ...
Sakthithasan, Kirushanthi, Lévy, Pierre, Poupon, Joel, Garnier, Robert   +3 more
openaire   +3 more sources

Paramagnetic salt and agarose recipes for phantoms with desired T1 and T2 values for low‐field MRI

NMR in Biomedicine, Volume 38, Issue 1, January 2025.
Recipes that use agarose mixed with one of four paramagnetic salts are developed (NiCl2 shown here), which can be used to create synthetic samples for field strengths below 0.55 T. The recipes' utility is demonstrated by targeting relaxation properties of five neurological tissues for fields ranging between 0.0065 and 0.55 T.
Kalina V. Jordanova, Carla C. Fraenza, Michele N. Martin, Ye Tian, Sheng Shen, Christopher E. Vaughn, Kevin J. Walsh, Casey Walsh, Charlotte R. Sappo, Stephen E. Ogier, Megan E. Poorman, Rui P. Teixeira, William A. Grissom, Krishna S. Nayak, Matthew S. Rosen, Andrew G. Webb, Steven G. Greenbaum, Velencia J. Witherspoon, Kathryn E. Keenan   +18 more
wiley   +1 more source