Results 91 to 100 of about 90,240,046 (296)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Finite Element analysis for Edge-to-Edge Technique to Treat Post-Mitral Valve Repair Systolic Anterior Motion [PDF]

, 2014
Systolic anterior motion of the mitral valve is an uncommon complication of mitral valve repair, which requires immediate supplementary surgical action.
Zhong, Q., Zeng, W., Huang, X., Zhao, X.
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Leaflet Injuries After Percutaneous Edge-to-Edge Repair

JACC: Case Reports, 2021
Francesco Maisano, MD
doaj   +1 more source

Clinical, Functional, and Quality‐of‐Life Outcomes After Contemporary Transcatheter Edge‐to‐Edge Repair for Primary Mitral Regurgitation in the Very Elderly

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Advanced age may influence the benefits derived from transcatheter edge‐to‐edge repair for primary mitral regurgitation (MR). We explored the impact of age on clinical, echocardiographic, functional, and patient‐reported outcomes after ...
Matthew J. Price, Gagan D. Singh, Jason H. Rogers, Michael J. Rinaldi, Paul Mahoney, Paolo Denti, Wolfgang Rottbauer, Federico M. Asch, Jose L. Zamorano, Janani Aiyer, Kelli Peterman, Francesco Maisano, Ralph Stephan von Bardeleben, Evelio Rodriguez, Saibal Kar   +14 more
doaj   +1 more source

Impact of Pulmonary Hypertension on Outcomes after Transcatheter Tricuspid Valve Edge-to-Edge Repair.

JACC: Cardiovascular Interventions
BACKGROUND Data regarding the association of pulmonary hypertension (PH) and outcomes in patients undergoing transcatheter tricuspid valve edge-to-edge repair (T-TEER) are scarce.
L. Stolz, Karl-Patrik Kresoja, Jennifer von Stein, V. Fortmeier, Benedikt Koell, W. Rottbauer, M. Kassar, B. Goebel, P. Denti, P. Achouh, T. Rassaf, M. Barreiro-Pérez, P. Boekstegers, A. Rück, P. Doldi, Julia Novotny, M. Zdanyte, M. Adamo, Flavien Vincent, P. Lurz, Ralph-Stephan von Bardeleben, T. Stocker, L. Weckbach, M. Wild, C. Besler, Stephanie Brunner, Stefan Toggweiler, J. Grapsa, Tiffany Patterson, H. Thiele, T. Kister, G. Tarantini, G. Masiero, M. D. De Carlo, A. Sticchi, M. Konstandin, E. van Belle, M. Metra, Tobias Geisler, R. Estévez-Loureiro, P. Luedike, N. Karam, Francesco Maisano, P. Lauten, F. Praz, M. Kessler, D. Kalbacher, V. Rudolph, C. Iliadis, J. Hausleiter, Roman Pfister, S. Baldus, M. Gerçek, F. Rudolph, Sebastian Ludwig, C. Pauschinger, L. Schneider, D. Felbel, C. Salomon, H. Lapp, T. Puscas, A. Berrebi, A. Mahabadi, F. Schindhelm, B. Caneiro-Queija, J. Echarte, Jürgen Schreieck, Andreas Goldschmied, E. Pancaldi, D. Tomasoni, N. Rousse, S. Aghezzaf, Norbert Frey, M. Kraus, D. Westermann, S. Rosch, Federico Arturi, Andrea Panza, Matteo Mazzola, C. Giannini   +79 more
semanticscholar   +1 more source

Edge-to-Edge Mitral Valve Repair With Extended Clip Arms: Early Experience From a Multicenter Observational Study. [PDF]

, 2019
OBJECTIVES The aim of this study was to investigate the technical success and efficacy of mitral valve edge-to-edge repair using extended clip arms.
Spirito, Alessandro, Brugger, Nicolas, Windecker, Stephan, Praz, Fabien, Spring, Karin, Blazek, Stephan, Braun, Daniel, Brinkmann, Isabel, Orban, Mathias, Lurz, Philipp, Unterhuber, Matthias, Thiele, Holger, Hausleiter, Jörg, Moschovitis, Aris, Nabauer, Michael, Pilgrim, Thomas, Brugger N, Thiele H, Windecker S, Nabauer M, Moschovitis A, Unterhuber M, Braun D, Spring K, Blazek S, Pilgrim T, Brinkmann I, Hausleiter J, Spirito A, Lurz P, Praz F, Orban M   +31 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Transcatheter edge-to-edge mitral valve repair in patients with acute decompensated heart failure due to severe mitral regurgitation

Cardiology Journal
BACKGROUND: Transcatheter edge-to-edge mitral valve repair (TEER) has been established as a therapy for severe symptomatic mitral regurgitation (MR) in stable patients, and it has recently emerged as a reasonable option for acutely ill patients.
Noam Makmal, Neta Silbermintz, Kobi Faierstein, Roy Raphael, Cathrine Moeller, Michal Canetti, Elad Maor, Rafi Kuperstein, Ilan Hai, Adi Butnaru, Daniel Oren, Israel M. Barbash, Victor Guetta, Paul Fefer   +13 more
doaj   +1 more source

Biphasic Right Ventricular Reverse Remodeling Following Tricuspid Valve Transcatheter Edge-to-Edge Repair.

JACC: Cardiovascular Interventions
BACKGROUND Transcatheter tricuspid valve edge-to-edge repair (T-TEER) has been reported to be associated with right ventricular reverse remodeling (RVRR). Data on the temporal evolution of this phenomenon are scarce.
L. Stolz, L. Weckbach, Hannah Glaser, P. Doldi, Simon Schmid, T. Stocker, Christian Hagl, M. Nabauer, S. Massberg, J. Hausleiter   +9 more
semanticscholar   +1 more source