Results 71 to 80 of about 90,240,046 (296)

Transcatheter edge-to-edge repair in secondary mitral regurgitation.

EuroIntervention
Secondary mitral regurgitation (SMR) is frequent among patients with heart failure (HF) with reduced ejection fraction (HFrEF), and it is strongly associated with increased mortality, frequent hospitalisations, and poor quality of life.
J. Rodés-Cabau, Siddhartha Mengi, E. Salaun, J. Paradis, William T. Abraham   +4 more
semanticscholar   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Patient Risk–Benefit Preferences for Transcatheter Versus Surgical Mitral Valve Repair

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Transcatheter edge‐to‐edge repair (TEER) of mitral regurgitation is less invasive than surgery but has greater 5‐year mortality and reintervention risks, and leads to smaller improvements in physical functioning.
Anna Hung, Jui‐Chen Yang, Matthew Wallace, Brittany A. Zwischenberger, Sreekanth Vemulapalli, Robert J. Mentz, Elizabeth Thoma, Scott Goates, John Lewis, Susan Strong, Shelby D. Reed   +10 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Swinburne Edge

, 2023
Swinburne Edge is powered by the Centre for the New Workforce – the only research facility in Australia dedicated to the latest and best workforce innovation ...
Swinburne Edge
core   +1 more source

Barlow’s Transcatheter Edge-to-Edge Repair in Mitral Annular Calcification

JACC: Case Reports
Objective: The presence of Barlow’s and mitral annular calcification poses significant challenges in mitral transcatheter edge-to-edge repair (M-TEER). Our case involved a patient with both pathologies who underwent successful 3-dimensional intracardiac ...
Leo Kar Lok Lai, MD, Hussayn Alrayes, DO, Georgi Fram, MD, James C. Lee, MD, John Dawdy, MD, Brian P. O’Neill, MD, Tiberio M. Frisoli, MD, Pedro Engel Gonzalez, MD, William W. O’Neill, MD, Pedro A. Villablanca, MD   +9 more
doaj   +1 more source

Update on the Current Status and Indications for Transcatheter Edge-to-Edge Mitral Valve Repair

, 2020
PURPOSE OF REVIEW: To review the current status and indications of transcatheter edge-to-edge mitral valve repair. RECENT FINDINGS: Mitral regurgitation remains a common valvular disease and can be classified as degenerative (primary) or functional ...
Chhatriwalla, Adnan K, Qintar, Mohammed
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Left Ventricular Flow Patterns after Percutaneous Edge-to-Edge Mitral Valve Repair: An in vitro Study [PDF]

, 2013
Percutaneous mitral valve edge-to-edge repair is a viable solution in high-risk patients with severe symptomatic mitral regurgitation. However, the generated double-orifice configuration poses challenges for the evaluation of the hemodynamic performance ...
Jeyhani, Morteza
core   +1 more source