Results 111 to 120 of about 2,538,869 (297)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Edge computing technologies for Internet of Things: a primer
Digital Communications and Networks, 2018 With the rapid development of mobile internet and Internet of Things applications, the conventional centralized cloud computing is encountering severe challenges, such as high latency, low Spectral Efficiency (SE), and non-adaptive machine type of ...
Yuan Ai, Mugen Peng, Kecheng Zhang
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2021 Edge computing provides the means for higher integration and seamless communication in industrial automation. Due to the paradigm´s distributed nature, it faces several security threats and safety hazards.
Hollerer, Siegfried; orcid: +3 more
core +2 more sources
5G edge computing technology and application prospects
Dianxin kexue, 2019 Edge computing is a method of processing data physically close to where data is generated,and it is one of the key technologies of 5G.The development of network technology and the demand of business applications have jointly promoted the maturity of 5G ...
Hongyuan MA +3 more
doaj +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Edge computing with peer to peer interactions
, 2019 Edge and fog computing applications typically focus on outsourcing computations from static or mobile end user devices towards compute nodes in proximity.
Venito, Alexandre +9 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Cooperative load balancing scheme for edge computing resources
, 2017 Edge Computing, as a solution to leveraging computation capabilities at the edge of the network, is emerging. One key challenge for edge computing is offering its computing service with a low service blocking and low latency that otherwise translate ...
Mtibaa, Abderrahmen +5 more
core +1 more source