Results 121 to 130 of about 2,538,869 (297)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Improved Double Deep Q Network-Based Task Scheduling Algorithm in Edge Computing for Makespan Optimization [PDF]

Edge computing nodes undertake more and more tasks as business density grows. How to efficiently allocate large-scale and dynamic workloads to edge computing resources has become a critical challenge. An edge task scheduling approach based on an improved
Liu, Xiaodong, Shen, Shigen, Zeng, Lei, Liu, Qi   +3 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Novel Task Caching and Migration Strategy in Multi-Access Edge Computing Based on the Genetic Algorithm

, 2019
Multi-access edge computing (MEC) brings high-bandwidth and low-latency access to applications distributed at the edge of the network. Data transmission and exchange become faster, and the overhead of the task migration between mobile devices and edge ...
Lujie Tang, Bing Tang, Linyao Kang, Li Zhang   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

FPGA-based accelerator method for Edge Computing [PDF]

Edge computing helps radio-supported mobile systems to process computing tasks on the side ofservers. The proximity to an edge computing node avoids excessive latencies, which benefits the calculation ofreal-time algorithms. Special computing needs arise
Schulz, Peter, Sleahtitchi, Grigore
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Fortified-Edge 2.0: Advanced Machine-Learning-Driven Framework for Secure PUF-Based Authentication in Collaborative Edge Computing

This research introduces Fortified-Edge 2.0, a novel authentication framework that addresses critical security and privacy challenges in Physically Unclonable Function (PUF)-based systems for collaborative edge computing (CEC).
Seema G. Aarella, Elias Kougianos, Venkata P. Yanambaka, Saraju P. Mohanty   +3 more
core   +1 more source

A functional and performance benchmark of lightweight virtualization platforms for edge computing

, 2022
The recent rise of edge computing and FaaS triggered a revolution in the field of software virtualization, improving performance and security. This paper benchmarks various lightweight virtualization platforms, such as microVMs and containers, in the ...
Goethals, TomTW050020041565078020028321330000-0002-1332-22908FAA44B2-136D-11E8-8BB2-082D12A95AF2, Al-Naday, Mays, De Turck, FilipTW058010011842650000-0003-4824-1199F551A7FE-F0ED-11E1-A9DE-61C894A0A6B4, Volckaert, BrunoTW050019973312428010015342730000-0003-0575-5894F62C7032-F0ED-11E1-A9DE-61C894A0A6B4, Chang, C. K.editor, Sebrechts, MerlijnTW050001311280348020021236290000-0002-4093-7338BA3F6DE8-2889-11E3-A8BB-B9B410BDE39D, Xhafa, F.editor, Ardagna, C. A.editor, Chang, R. N.editor, Puig, V.editor, He, Q.editor, Damiani, E.editor, Bian, H.editor, Ward, R.editor, Elia, G.editor, Zhang, J.editor   +15 more
core  

Development status and trend prospect of computing power infrastructure

Dianxin kexue, 2022
The development of digital technology drives the change and revolution of computing power infrastructure.The computing power infrastructure mainly referes to hardware and software infrastructure related to cloud computing, edge computing, end computing ...
Wenjuan XING, Bo LEI, Qianying ZHAO
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