Results 121 to 130 of about 5,254,563 (393)
FEBS Letters, EarlyView.We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring +6 more
wiley +1 more source
Optimal Pricing-Based Edge Computing Resource Management in Mobile Blockchain
, 2017 As the core issue of blockchain, the mining requires solving a proof-of-work puzzle, which is resource expensive to implement in mobile devices due to high computing power needed.
Feng, Shaohan +4 more
core +1 more source
FEBS Letters, EarlyView.We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon +5 more
wiley +1 more source
, 2021 Abstract—Latest generation mobile networks aim to use multi-tier heterogeneous cellular networks integrated with cloud computing to provide users with low latency and energy-aware service. However, for high bandwidth and low latency services, edge/fog computing comes into the scenario.
openaire +2 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Edge Intelligence: The Confluence of Edge Computing and Artificial Intelligence [PDF]
, 2019 Along with the rapid developments in communication technologies and the surge in the use of mobile devices, a brand-new computation paradigm, Edge Computing, is surging in popularity. Meanwhile, Artificial Intelligence (AI) applications are thriving with the breakthroughs in deep learning and the many improvements in hardware architectures. Billions of
arxiv +1 more source
Federated Learning in Vehicular Edge Computing: A Selective Model Aggregation Approach
IEEE Access, 2020 Federated learning is a newly emerged distributed machine learning paradigm, where the clients are allowed to individually train local deep neural network (DNN) models with local data and then jointly aggregate a global DNN model at the central server ...
Dongdong Ye, Rong Yu, M. Pan, Zhu Han
semanticscholar +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Development status and trend prospect of computing power infrastructure
Dianxin kexue, 2022 The development of digital technology drives the change and revolution of computing power infrastructure.The computing power infrastructure mainly referes to hardware and software infrastructure related to cloud computing, edge computing, end computing ...
Wenjuan XING, Bo LEI, Qianying ZHAO
doaj +2 more sources
Developing an edge computing platform for real-time descriptive analytics [PDF]
, 2017 The Internet of Mobile Things encompasses stream data being generated by sensors, network communications that pull and push these data streams, as well as running processing and analytics that can effectively leverage actionable information for transportation planning, management, and business advantage.
arxiv +1 more source