Results 51 to 60 of about 115,069 (250)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Bearing thinking of edge computing based on NFV
Dianxin kexue, 2018 Aiming at introducing edge computing into operator’s network,a bearing and deployment thinking based on NFV was presented.Firstly,the industry development trends of edge computing were introduced.Then the concept,service scenarios and special ...
Yujia LUO, Liang OU, Hong TANG
doaj +2 more sources
Applied Sciences, 2022 With the rapid development of wireless networks, wireless edge computing networks have been widely considered. The heterogeneous characteristics of the 6G edge computing network bring new challenges to network resource scheduling.
Yaofang Li, Bin Wu
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Cloud native based edge computing: vision and challenges
物联网学报, 2021 Cloud native computing, featured by low-cost container technology, well fits edge computing.It was proposed to apply cloud native computing to make edge computing resource management and control transparent to application development and operation ...
Deze ZENG +3 more
doaj +2 more sources
Data Security and Privacy-Preserving in Edge Computing Paradigm: Survey and Open Issues
IEEE Access, 2018 With the explosive growth of Internet of Things devices and massive data produced at the edge of the network, the traditional centralized cloud computing model has come to a bottleneck due to the bandwidth limitation and resources constraint.
Jiale Zhang +4 more
doaj +1 more source
CoRRMobile Edge Computing (MEC) has emerged as a solution to the high latency and suboptimal Quality of Experience (QoE) associated with Mobile Cloud Computing (MCC). By processing data near the source, MEC reduces the need to send information to distant data centers, resulting in faster response times and lower latency. This paper explores the differences
Sohaib Ahmed +3 more
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source