Results 71 to 80 of about 2,538,869 (297)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Edge/Fog Computing Technologies for IoT Infrastructure [PDF]

open access: yes, 2021
The prevalence of smart devices and cloud computing has led to an explosion in the amount of data generated by IoT devices. Moreover, emerging IoT applications, such as augmented and virtual reality (AR/VR), intelligent transportation systems, and smart ...

core   +1 more source

Bearing thinking of edge computing based on NFV

open access: yesDianxin kexue, 2018
Aiming at introducing edge computing into operator’s network,a bearing and deployment thinking based on NFV was presented.Firstly,the industry development trends of edge computing were introduced.Then the concept,service scenarios and special ...
Yujia LUO, Liang OU, Hong TANG
doaj   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Cloud native based edge computing: vision and challenges

open access: yes物联网学报, 2021
Cloud native computing, featured by low-cost container technology, well fits edge computing.It was proposed to apply cloud native computing to make edge computing resource management and control transparent to application development and operation ...
Deze ZENG   +3 more
doaj   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Edge-supported microservice-based resource discovery for mist computing [PDF]

open access: yes, 2020
Mist computing extends the Internet of Things computing infrastructures to the IoT devices at the edges of the networks. The dynamic characteristics of the IoT environments and resource limitations of the devices introduce challenges to the orchestration
Teemu Leppanen   +14 more
core   +1 more source

Data Security and Privacy-Preserving in Edge Computing Paradigm: Survey and Open Issues

open access: yesIEEE Access, 2018
With the explosive growth of Internet of Things devices and massive data produced at the edge of the network, the traditional centralized cloud computing model has come to a bottleneck due to the bandwidth limitation and resources constraint.
Jiale Zhang   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Efficient Hosting of Robust IoT Applications on Edge Computing Platform

open access: yes, 2020
Demanding IoT application requirements such as high dependability and low latency, cannot be satisfied by centralized cloud computing when deploying these applications.
Pop, Paul   +7 more
core   +1 more source

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