Results 81 to 90 of about 2,538,869 (297)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Edge and Cloud Computing in Smart Cities
The evolution of smart cities is intrinsically linked to advancements in computing paradigms that support real-time data processing, intelligent decision-making, and efficient resource utilization.
Elias Dritsas, Maria Trigka
core +1 more source
, 2019 Mobile applications are becoming increasingly computational-intensive while many mobile devices still have limited battery power and cannot support computational intensive tasks Mobile edge computing MEC computing is an extension of edge computing ...
Chandra M. M. Kotteti +2 more
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
PECSA: Practical Edge Computing Service Architecture Applicable to Adaptive IoT-Based Applications
, 2021 The cloud-based Internet of Things (IoT-Cloud) combines the advantages of the IoT and cloud computing, which not only expands the scope of cloud computing but also enhances the data processing capability of the IoT.
Jianhua Liu, Zibo Wu
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Security of intelligent edge computing:a survey
Dianxin kexue, 2018 With the rise of edge computing,more and more attentions have been paid to security issues of edge computing.The basic concepts,system architecture and the relationship between edge computing and other computing paradigms were introduced.Then the ...
Xingshuo AN +4 more
doaj +2 more sources
Computing on the Edge of the Network.
, 2021 To enable fifth generation cellular communication network (5G) systems, energy efficient architectures are required that can provide a reliable service platform for the delivery of 5G services and beyond. Device Enhanced Edge Computing is a derivative of Multi-Access Edge Computing (MEC), which provides computing and storage resources directly on the ...
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
IEEE Access Special Section Editorial: Mobile Edge Computing
IEEE Access, 2020 Mobile edge computing (MEC) is emerging as a promising computing architecture by pushing computation and storage closer to end-users with both strategically deployed edge servers and opportunistic available resources.
Yan Zhang +6 more
doaj +1 more source