Results 71 to 80 of about 5,372,457 (283)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Optimization of Contact Edge Profile for Minimizing Contact Pressure in a Press-fitted Shaft
MATEC Web of Conferences, 2018 In the shrink or press-fitted shafts such as railway axles, the rotor of a steam turbine or coupling, a high-stress concentration takes place in the close of contact edge due to relative slip between shaft and boss in a press-fitted shaft and this is a ...
Lee Dong-Hyung +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Scientific Reports, 2014 Spin transport features of the n-type doping zigzag graphene nanoribbons (ZGNRs) with an edge contact are investigated by first principle methods, where ZGNRs are C–H2 bonded at one edge while C–H bonded at the other to form an asymmetric edge ...
X. Deng +5 more
semanticscholar +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Applied Sciences, 2018 Rigid gas permeable (RGP) contact lenses are a common presbyopic correction tool. However, many patients clinically need a long period of adaptation after wearing.
Han-Chao Chang +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Jixie chuandong, 2009 The tooth edge contact of face gear drive with spur pinion isunavoidable. The meshing of face gear drive with spur pinion is investigated. A mathematical model and a constraint condition are developed, by which the contact points on tooth edge could be ...
沈云波, 方宗德, 赵宁, 魏冰阳
doaj
Apparatus for cutting elastomeric materials [PDF]
, 1974 Sharp thin cutting edge is held in head of milling machine designed for metal working. Controls of machine are used to position cutting edge in same plane as vibrating specimen. Controls then are operated, making blade come into contact with specimen, to
Corbett, A. B.
core +1 more source
Electrical transport across metal/two-dimensional carbon junctions: Edge versus side contacts
, 2012 Metal/two-dimensional carbon junctions are characterized by using a nanoprobe in an ultrahigh vacuum environment. Significant differences were found in bias voltage (V) dependence of differential conductance (dI/dV) between edge- and side-contact; the ...
Hua, Younan +8 more
core +2 more sources