Results 81 to 90 of about 1,689,337 (289)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Disordered contacts can localize helical edge electrons [PDF]
Journal of Physics: Condensed Matter, 2019 Abstract It is well known that quantum spin Hall (QSH) edge modes being helical are immune to backscattering due to non-magnetic disorder within the sample. Thus, QSH edge modes are non-localized and show a vanishing Hall resistance along with quantized 2-terminal, longitudinal and non-local resistances even in ...
Arjun Mani, Colin Benjamin
openaire +3 more sources
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
FEM Studies of CMP Retainer Ring Using Metamodel [PDF]
한국정밀공학회지This study introduces a novel retainer ring design aimed at mitigating the edge effect during chemical mechanical planarization. The innovative design features an arch-shaped geometry that creates a bending effect, thereby reducing excessive pressure on ...
Do Yeong Jung +6 more
doaj +1 more source
Non-equilibrium noise in the (non-)Abelian fractional quantum Hall effect [PDF]
, 2014 We analyse the noise of the edge current of a generic fractional quantum Hall state in a tunnelling point contact system. We show that the non-symmetrized noise in the edge current for the system out-of-equilibrium is completely determined by the noise ...
Simon, Steven H. +2 more
core +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Jixie chuandong, 2009 The tooth edge contact of face gear drive with spur pinion isunavoidable. The meshing of face gear drive with spur pinion is investigated. A mathematical model and a constraint condition are developed, by which the contact points on tooth edge could be ...
沈云波, 方宗德, 赵宁, 魏冰阳
doaj
Role of chemical termination in edge contact to graphene
APL Materials, 2014 Edge contacts to graphene can offer excellent contact properties. Role of different chemical terminations is examined by using ab initio density functional theory and quantum transport simulations. It is found that edge termination by group VI elements O
Qun Gao, Jing Guo
doaj +1 more source
Applied Sciences, 2018 Rigid gas permeable (RGP) contact lenses are a common presbyopic correction tool. However, many patients clinically need a long period of adaptation after wearing.
Han-Chao Chang +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source