Results 81 to 90 of about 266,197 (292)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A single layer spin-orbit torque nano-oscillator

Nature Communications, 2019
Spin torque nano-oscillatiors promise novel microwave applications but the functioning relies on the spin current from additional ferromagnetic or metal layers.
Mohammad Haidar, Ahmad A. Awad, Mykola Dvornik, Roman Khymyn, Afshin Houshang, Johan Åkerman   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Edge Localized Mode Control in TCV

, 2012
The Tokamak concept, based on magnetic confinement of a hydrogen plasma, is one of today's most promising paths to energy production by nuclear fusion. The experimental scenarios leading to the largest fusion rate are based on a high confinement plasma regime, the H-mode, in which the energy and particle confinement are enhanced by a transport barrier ...
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Experimental observation and edge characteristics of EDA H-mode on the HL-3 tokamak

Nuclear Fusion
The enhanced ${D_\alpha }$ (EDA) H-mode features high energy confinement together with the absence of edge localized modes (ELMs) and impurity accumulation, making it highly attractive for fusion reactors. The EDA H-mode has been observed recently in the
Anshu Liang, Xiaolan Zou, Wulyu Zhong, Yu Zhou, Guoliang Xiao, Rui Ke, Wenping Guo, Shaobo Gong, Liang Liu, Tengfei Sun, Na Wu, Min Jiang, Yiren Zhu, Shiqin Wang, Guanqun Xue, Xin Yu, Jie Wen, Deliang Yu, Zhongbing Shi, Bo Li, Wei Chen, Xiaoquan Ji   +21 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of toroidal Alfvén Eigenmode nonlinearity on edge localized mode in HL-2A NBI heated H-mode plasmas

Nuclear Fusion
The present paper reports the observation of shear Alfvénic wave fluctuations prior to the edge localized mode (ELM) crash in HL-2A NBI H-mode plasmas.
X.L. Zhu, W. Chen, J. Bao, R. Ke, P.W. Shi, L.M. Yu, Z.B. Shi, Z.Y. Qiu, M. Jiang, H.L. Wei, Y.G. Li, X.X. He, Z.C. Yang, Y.P. Zhang, D.L. Yu, H.T. Chen, R.R. Ma, Z.X. Wang, J.Q. Li, W.L. Zhong   +19 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Helical edge magnetoplasmon in the quantum Hall effect regime

, 2010
We present the microscopic treatment of edge magnetoplasmons (EMPs) for the regime of not-too-low temperatures defined by the condition $\hbar \omega_{c}\gg k_{B}T\gg \hbar v_{g}/2\ell_{0}$, where $v_{g}$ is the group velocity of the edge states, $\ell_ ...
Balev, Oleg G., Silva, Sanderson
core   +1 more source