Results 61 to 70 of about 48,614 (262)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Experimental observation and edge characteristics of EDA H-mode on the HL-3 tokamak

Nuclear Fusion
The enhanced ${D_\alpha }$ (EDA) H-mode features high energy confinement together with the absence of edge localized modes (ELMs) and impurity accumulation, making it highly attractive for fusion reactors. The EDA H-mode has been observed recently in the
Anshu Liang, Xiaolan Zou, Wulyu Zhong, Yu Zhou, Guoliang Xiao, Rui Ke, Wenping Guo, Shaobo Gong, Liang Liu, Tengfei Sun, Na Wu, Min Jiang, Yiren Zhu, Shiqin Wang, Guanqun Xue, Xin Yu, Jie Wen, Deliang Yu, Zhongbing Shi, Bo Li, Wei Chen, Xiaoquan Ji   +21 more
doaj   +1 more source

Impurity accumulation and edge localized mode(ELM).

Kakuyūgō kenkyū, 1988
The effect of the impurity ions on the L/ H and H/ L transitions in tokamaks is discussed. It is found that the impurity accumulation can trigger the transition from the H-mode to the L-mode. The relation with ELM is also discussed.
Ohkawa, Tihiro, Itoh, Kimitaka, Itoh, Sanae-I.   +2 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Effect of toroidal Alfvén Eigenmode nonlinearity on edge localized mode in HL-2A NBI heated H-mode plasmas

Nuclear Fusion
The present paper reports the observation of shear Alfvénic wave fluctuations prior to the edge localized mode (ELM) crash in HL-2A NBI H-mode plasmas.
X.L. Zhu, W. Chen, J. Bao, R. Ke, P.W. Shi, L.M. Yu, Z.B. Shi, Z.Y. Qiu, M. Jiang, H.L. Wei, Y.G. Li, X.X. He, Z.C. Yang, Y.P. Zhang, D.L. Yu, H.T. Chen, R.R. Ma, Z.X. Wang, J.Q. Li, W.L. Zhong   +19 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The formation of an radial edge electric field due to finite ion orbit width effects is the possible root cause of the H-mode edge

Nuclear Fusion
Full orbit-following simulations of thermal ions show that finite ion-orbit width effects create charge separation near the last closed flux surface (LCFS) which generates a localized radial electric field.
G.J. Kramer, A. Bortolon, A. Diallo, R. Maingi   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Tokamak edge localized mode onset prediction with deep neural network and pedestal turbulence

Nuclear Fusion
A neural network, BES-ELMnet, predicting a quasi-periodic disruptive eruption of the plasma energy and particles known as edge localized mode (ELM) onset is developed with observed pedestal turbulence from the beam emission spectroscopy system in DIII-D.
Semin Joung, David R. Smith, G. McKee, Z. Yan, K. Gill, J. Zimmerman, B. Geiger, R. Coffee, F.H. O’Shea, A. Jalalvand, E. Kolemen   +10 more
doaj   +1 more source