Results 41 to 50 of about 48,614 (262)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Topological Corner Modes in Graphene-Coated Nanowire Waveguide

Applied Sciences, 2020
We study the plasmonic second-order topological modes in nanowire waveguides which are covered by monolayer graphene. The waveguide arrays are arranged in the kagome lattice. In a triangle-shaped lattice, the topological modes are localized at the corner
Ningliang Liu, Chizhu Ding, Qing Liao, Shaolin Ke   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Nonlinear modeling of ELM mitigation with RMP on HL-2A

Nuclear Fusion
Nonlinear modeling of mitigation of the edge localized mode (ELM) with resonant magnetic perturbation (RMP) is performed for the HL-2A tokamak, utilizing the three-dimensional (3D) magnetohydrodynamic code JOREK.
L. Wang, G.Z. Hao, M. Becoulet, Y.Q. Liu, Y.H. Xu, J.Q. Li, P.F. Zheng, D. Hu, S.L. Hu, G.Q. Dong, S. Wang, X.X. He, T.F. Sun, G.T.A. Huijsmans, W.L. Zhong, the JOREK Team   +15 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The effect of the plasma response on peeling–ballooning modes during edge localized modes mitigated by resonant magnetic perturbations

Nuclear Fusion, 2023
The effects of resonant magnetic perturbation (RMP) fields on peeling–ballooning (P–B) modes are studied with the experimental equilibria of EAST based on the four-field model in BOUT++ code.
L.K. Dong, S.Y. Chen, M.L. Mou, Y. Luo, C.C. Qin, C.J. Tang   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nonlinear edge-localized mode with impurity seeding in CFETR hybrid scenario

Nuclear Fusion
A critical challenge for operating fusion burning plasma in high-confinement mode lies in mitigating damage caused by edge-localized modes (ELMs).
Shiyong Zeng, Ping Zhu
doaj   +1 more source

Effect of coherent edge-localized mode on transition to high-performance hybrid scenarios in KSTAR

Nuclear Fusion, 2023
This paper deals with one of the origins and trigger mechanisms responsible for the observed performance enhancements in the hybrid scenario experiments conducted in Korea Superconducting Tokamak Advanced Research (KSTAR).
Youngho Lee, S.K. Kim, J.W. Kim, B. Kim, M.S. Park, J.M. Kwon, M.J. Choi, S.H. Hahn, M.W. Lee, S.M. Yang, S.C. Hong, C.Y. Lee, S.J. Park, C.S. Byun, H.-S. Kim, J. Chung, Yong-Su Na   +16 more
doaj   +1 more source