Results 71 to 80 of about 48,614 (262)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Toroidal asymmetries in divertor impurity influxes in NSTX

Nuclear Materials and Energy, 2017
Toroidal asymmetries in divertor carbon and lithium influxes were observed in NSTX, due to toroidal differences in surface composition, tile leading edges, externally-applied three-dimensional (3D) fields and toroidally-localized edge plasma ...
F. Scotti, V.A. Soukhanovskii, J.-W. Ahn, A.G. McLean, R. Kaita   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Investigation of LHCD capabilities in I-mode plasma on EAST tokamak

Nuclear Fusion
Improved energy confinement mode (I-mode) regime offers promising confinement characteristics with temperature pedestal and low-confinement mode (L-mode) like particle transport.
C.B. Wu, B.J. Ding, M.H. Li, X.L. Zou, X.M. Zhong, A.D. Liu, Y.Q. Chu, X.H. Wu, S.Y. Lin, Y.F. Jin, E.Z. Li, M. Wang, X.J. Wang, H.Q. Liu, Q. Zang, J.S. Gen, Y.H. Cao, J.L. Chen, W. Sun, H.W. Zhao, G.B. Zhang, W.W. Zhang, X.X. Wang, X.Z. Gong, Y.T. Song, EAST I-mode Working Group, the EAST Team   +26 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Simultaneous access to high normalized density, current, pressure, and confinement in strongly-shaped diverted negative triangularity plasmas

Nuclear Fusion
Strongly-shaped diverted negative triangularity (NT) plasmas in the DIII-D tokamak demonstrate simultaneous access to high normalized density, current, pressure, and confinement.
C. Paz-Soldan, C. Chrystal, P. Lunia, A.O. Nelson, K.E. Thome, M.E. Austin, T.B. Cote, A.W. Hyatt, N. Leuthold, A. Marinoni, T.H. Osborne, M. Pharr, O. Sauter, F. Scotti, T.M. Wilks, H.S. Wilson   +15 more
doaj   +1 more source

Edge Localized Mode Control in TCV

, 2012
The Tokamak concept, based on magnetic confinement of a hydrogen plasma, is one of today's most promising paths to energy production by nuclear fusion. The experimental scenarios leading to the largest fusion rate are based on a high confinement plasma regime, the H-mode, in which the energy and particle confinement are enhanced by a transport barrier ...
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source