Results 41 to 50 of about 8,828 (263)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Dynamic energy balanced max flow routing in energy-harvesting sensor networks

International Journal of Distributed Sensor Networks, 2017
We propose a dynamic energy balanced max flow routing algorithm to maximize load flow within the network lifetime and balance energy consumption to prolong the network lifetime in an energy-harvesting wireless sensor network.
Bin Cai, Shan-Li Mao, Xiao-Hui Li, Yue-Min Ding   +3 more
doaj   +1 more source

Hybrid Edge Capacity Routing in Complex Networks

Journal of Networks, 2016
The main focus on the algorithmic theory is the network optimization. The goal of network optimization is to connect vertices of the network in an inexpensive manner. In this work we present an efficient algorithm to achieve the effective optimization for an undirected large scale graph.
P. Ranjana, A. George
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Bayesian Multi-Armed Bandit Algorithm for Dynamic End-to-End Routing in SDN-Based Networks with Piecewise-Stationary Rewards

Algorithms, 2023
To handle the exponential growth of data-intensive network edge services and automatically solve new challenges in routing management, machine learning is steadily being incorporated into software-defined networking solutions.
Pedro Santana, José Moura
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Homotopic Rectilinear Routing with Few Links and Thick Edges [PDF]

, 2010
We study the problem of finding non-crossing thick minimum-link rectilinear paths homotopic to a set of input paths in an environment with rectangular obstacles. This problem occurs in the context of map schematization under geometric embedding restrictions, for example, when schematizing a highway network for use as a thematic layer.
Bettina Speckmann, Kevin Verbeek
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Nash equilibria in routing games with edge priorities

CoRR, 2018
In this paper we present a new competitive packet routing model with edge priorities. We consider players that route selfishly through a network over time and try to reach their destinations as fast as possible. If the number of players who want to enter an edge at the same time exceeds the inflow capacity of this edge, edge priorities with respect to ...
Robert Scheffler 0001, Martin Strehler 0001, Laura Vargas Koch   +2 more
openaire   +2 more sources