Results 51 to 60 of about 8,828 (263)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Computation Offloading and Resource Allocation for E2E Tasks in Satellite Edge Computing Networks

Space: Science & Technology
Satellite edge computing shows promise in delivering seamless, low-latency services in challenging contexts such as deserts, oceans, and during natural disasters.
Yunbo Qu, Tingting Zhang, Yuan Feng, Tongyang Xu, Zijian Guo   +4 more
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Analysis of MPLS/BGP/VPN Performance Advertising BGP Routing Algorithm

TecnoLógicas, 2013
The provider edge router of the service provider establishes VPNs (Virtual Private Network) performing routing between users and core network through the virtual routers (VR). The virtual routers develop routing to the networking MPLS/VPN/BGP through VRF
Mónica Espinosa-Buitrago, Octavio Salcedo-Parra, Ricardo Goméz-Vargas   +2 more
doaj  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Mosaic: in-memory computing and routing for small-world spike-based neuromorphic systems

Nature Communications
The brain’s connectivity is locally dense and globally sparse, forming a small-world graph—a principle prevalent in the evolution of various species, suggesting a universal solution for efficient information routing.
Thomas Dalgaty, Filippo Moro, Yiğit Demirağ, Alessio De Pra, Giacomo Indiveri, Elisa Vianello, Melika Payvand   +6 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Routing attack induced anomaly detection in IoT network using RBM-LSTM

ICT Express
The network of resource constraint devices, also known as the Low power and Lossy Networks (LLNs), constitutes the edge tire of the Internet of Things applications like smart homes, smart cities, and connected vehicles. The IPv6 Routing Protocol over Low
Rashmi Sahay, Anand Nayyar, Rajesh Kumar Shrivastava, Muhammad Bilal, Simar Preet Singh, Sangheon Pack   +5 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source