Results 51 to 60 of about 1,081,243 (285)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Bulk-and-edge to corner correspondence
Physical Review Research, 2020 We show that two-dimensional band insulators, with vanishing bulk polarization, obey bulk-and-edge to corner charge correspondence, stating that the knowledge of the bulk and the two corresponding ribbon band structures uniquely determines a fractional ...
Luka Trifunovic
doaj +1 more source
Finding Maximum Edge-Disjoint Paths Between Multiple Terminals
SIAM Journal on Computing, 2023 37 pages, 9 ...
Satoru Iwata 0001, Yu Yokoi
openaire +4 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Nuclear Materials and Energy, 2017 Two different plasma termination processes by dust emission were observed in long pulse discharges in the Large Helical Device. One is a plasma termination caused by large amounts of carbon dust released from a lower divertor region.
M. Shoji +6 more
doaj +1 more source
Efficient Completion of Weighted Automata [PDF]
Electronic Proceedings in Theoretical Computer Science, 2016 We consider directed graphs with edge labels from a semiring. We present an algorithm that allows efficient execution of queries for existence and weights of paths, and allows updates of the graph: adding nodes and edges, and changing weights of ...
Johannes Waldmann
doaj +1 more source
The small genome segment of Bunyamwera orthobunyavirus harbours a single transcription-termination signal [PDF]
, 2012 Transcription termination of the mRNA produced from the small (S) genome segment of Bunyamwera orthobunyavirus (BUNV) has previously been mapped to two cis-acting sequences located within the 5′ UTR using a virus-free replication assay.
Elliott, Richard Michael +5 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source