Results 71 to 80 of about 1,081,243 (285)
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Proving Termination of Input-Consuming Logic Programs [PDF]
, 1999 A class of predicates is identified for which termination does not depend on left-to-right execution. The only assumption about the selection rule is that derivations are input-consuming, that is, in each derivation step, the input arguments of the ...
Smaus, Jan-Georg
core
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Mechanism behind the recombination requirement for benign termination of relativistic electron beams
Nuclear FusionWe present a first-principles explanation of the recombination requirement for benign termination of relativistic electron (RE) beams in tokamaks. Kinetic modeling including neutrals shows that a specific range in injected neutral quantity results in ...
G. Su +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Chip size dependent dynamic behavior of SiC MOSFETs with edge termination
Power Electronic Devices and ComponentsThis study investigates the impact of the active-to-termination area ratio on the dynamic behavior of SiC MOSFETs. As the chip size decreases, the turn-on speed increases due to the reduced input capacitance.
Y. Kim, H. Kang
doaj +1 more source
Geometrical Mesh Improvement Properties of Delaunay Terminal Edge Refinement [PDF]
, 2006 The use of edge based refinement in general, and Delaunay terminal edge refinement in particular are well established for adaptive meshing, but largely on a heuristic basis. In this paper, we present some theoretical results on geometric improvement, and it limitations, for these methods.
Simpson, Bruce +1 more
openaire +4 more sources