Results 81 to 90 of about 40,649 (287)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effective edge termination design in SiCVJFET

, 2004
The current work investigates the edge termination techniques required to realize SiC Vertical Junction Field Effect Transistor (VJFET). Simulation results obtained using Silvaco TCAD tools have shown that the periphery fingers with metal contacts on ...
Bhatnagar P; Wright NG; Vassilevski KV; O'Neill AG; Horsfall AB; Johnson CM
core  

A novel sloped field plate-enhanced ultra-short edge termination structure

, 2016
A novel sloped field plate (FP)-enhanced ultra-short edge termination structure is proposed and experimentally demonstrated. The structure features a benzocyclobutene dielectric filled trench, and is fabricated along with a high-voltage p-i-n diode.
Yang, Wentao, Feng, Hao, Tanaka, Hiroyuki, Fang, Xiangming, Onozawa, Yuichi, Sin, Johnny K.O.   +5 more
core   +1 more source

Cloud-Edge-Terminal Collaborative AIGC for Autonomous Driving

IEEE Wireless Communications
In dynamic autonomous driving environment, Artificial Intelligence-Generated Content (AIGC) technology can supplement vehicle perception and decision making by leveraging models' generative and predictive capabilities, and has the potential to enhance motion planning, trajectory prediction and traffic simulation.
Jianan Zhang, Zhiwei Wei, Boxun Liu, Xiayi Wang, Yong Yu, Rongqing Zhang 0001   +5 more
openaire   +2 more sources

Universal terminal for mobile edge-quantum computing

, 2022
To bring the quantum computing capacities to the personal edge devices, the optimum approach is to have simple non-error corrected personal devices that offload the computational tasks to scalable quantum computers via edge servers with cryogenic components and fault-tolerant schemes. Hence the network elements deploy different encoding protocols. This
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A robust and area-efficient guard ring edge termination technique for 4H-SiC power MOSFETs

, 2017
A robust and area efficient adjusted multi-section guard rings (AMS) edge termination structure is employed to a 4H-SiC power MOSFET device rated at 1.7 kV and fabricated without extra process steps or masks in this paper.
Chen, Ximing, Chen, Wanjun, Zhang, Yourun, Ximing Chen, Deng, Xiaochuan, Wanjun Chen, Dai, Tianxiang, Li, Chengzhan, Yuanxu Guo, Chengzhan Li, Yourun Zhang, Zhang, Bo, Guo, Yuanxu, Bo Zhang, Xiaochuan Deng, Tianxiang Dai   +15 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Chip size dependent dynamic behavior of SiC MOSFETs with edge termination

Power Electronic Devices and Components
This study investigates the impact of the active-to-termination area ratio on the dynamic behavior of SiC MOSFETs. As the chip size decreases, the turn-on speed increases due to the reduced input capacitance.
Y. Kim, H. Kang
doaj   +1 more source