Results 111 to 120 of about 9,410,480 (347)

Understanding Quantitative Circadian Regulations Are Crucial Towards Advancing Chronotherapy

open access: yesCells, 2019
Circadian rhythms have a deep impact on most aspects of physiology. In most organisms, especially mammals, the biological rhythms are maintained by the indigenous circadian clockwork around geophysical time (~24-h).
Debajyoti Chowdhury   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Distance education at conventional universities in Germany [PDF]

open access: yes, 2010
Germany’s educational system has undergone a series of transformations during the last 40 years. In recent years, marked increases in enrolment have occurred.
Kappel, Hans-Henning   +2 more
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

High Marks for Lynch 7/29/2005 [PDF]

open access: yes, 2005
Approval of the job John Lynch is doing as New Hampshire governor continues to rise. And despite continuing concerns over education funding, New Hampshire residents are increasingly optimistic that the state is on the right ...
Survey Center, UNH
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source

Enhancing Student Learning Experiences and Providing Value to the Agribusiness Industry by Building the Industry-Institution Interface [PDF]

open access: yes
This paper addresses agribusiness industry-institution interfaces, research-education linkages, and improving agribusiness education with opportunities such as agricultural students’ internships with agribusiness companies, conducting applied research ...
Devadoss, Stephen, Foltz, John C.
core   +1 more source

Two Dreams, One Degree [PDF]

open access: yes, 2017
After a long night of body checks, slapshots and chasing a puck up and down the ice, Michael McCurtain ’16 often retreated to his hotel room – to tackle accounting homework.
Davis, Laura
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

MULTI-PROFESSIONAL RESIDENCY AS AN INTERCESSOR FOR CONTINUING EDUCATION IN HEALTH

open access: yes, 2016
The objective in this study is to understand how Continuing Education in Health is developed in the everyday life of professionals in a multi-professional residency program in health at a teaching hospital in the South of Brazil.
Cristiane Trivislol da Silva   +4 more
semanticscholar   +1 more source

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