Results 51 to 60 of about 555,484 (312)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Curriculum Development of Educational Technology Graduate Degree with a focus on Special Education in Iran [PDF]

پژوهش در نظام‌های آموزشی, 2018
The aim of this study was to develop a graduate degree in educational technology curriculum with a focus on special education in Iran. The method of research was descriptive-analytic and compatible with Brady method.
Esmaeil Zaraii Zavaraki
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Program Director Retention and Attrition Rates in International Graduate Medical Education

, 2020
Background Program directors (PDs) are integral to the education of the next generation of physicians. Yet, administrative burdens, substantial patient care responsibilities, and lack of protected time for teaching may contribute to work-life imbalance ...
Ibrahim H, Stadler DJ, Dutta D, Archuleta S, Cofrancesco J   +4 more
core   +1 more source

Integrated Management Plan for Graduate Medical Education and Accreditation Bodies in Korea [PDF]

, 2018
Graduate medical education is the most important phase among the three stages of medical education. It links basic medical education and continuing professional development.
연세대학교 의과대학
core   +1 more source

Tracking student progress through graduate programs

Discover Education
Higher education is awash with data that, when refined, facilitates data-informed decisions. Such decision-making is much more prevalent in support of undergraduate education given the much larger number of undergraduates pursuing higher education in ...
Michael E. Young, Megan Miller, Christopher Urban, Claudia Petrescu   +3 more
doaj   +1 more source

Historically underrepresented students: influences of rurality, parent education level and family income on graduate school intentions

Frontiers in Education
IntroductionDespite increasing rates of graduate school attendance, students from historically underrepresented backgrounds enroll in graduate programs at lower rates than their peers.
Kody K. Sexton, Melinda M. Gibbons, Erin E. Hardin, Katherine D. Cook, Jess Hoch, Haley R. Ault   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Internationalisation of UK Higher Education: From ‘technical observance’ to ‘relational participation’, the road to CAPRI… [PDF]

, 2009
This article reflects on a review of the literature on the internationalisation of UK higher education (HE) commissioned by the Higher Education Academy (HEA) in 2006.
Caruana, V
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source