Results 31 to 40 of about 656,718 (249)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

The bumpy road to change: a retrospective qualitative study on formerly detained adolescents’ trajectories towards better lives

Child and Adolescent Psychiatry and Mental Health, 2019
Background Currently, the risk-oriented focus in forensic youth care is increasingly complemented by a growing interest in strengths-based approaches.
Nele Van Hecke, Wouter Vanderplasschen, Lore Van Damme, Stijn Vandevelde   +3 more
doaj   +1 more source

The Study into Theoretical and Methodological Readiness of Defectology Students to Pursue Master Degree Programmes

Интеграция образования, 2021
Introduction.Training a competitive specialist at the level of a master program is an important educational goal. The problem of the continuity of educational levels as a condition for the quality of graduate training is debatable, because the focus of ...
Alla V. Zakrepina, Elena A. Shilova, Elena A. Strebeleva   +2 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Storytelling Method using Finger Pool to Improve the Expressive Language Ability of Moderately Independent Students Class II SDN Raharja Tanjungsari

Journal of Education for Sustainability and Diversity, 2023
The purpose of this research is to improve the expressive language skills of mentally retarded students in class II SLB Raharja Mandiri using the storytelling method through finger puppet media. This study uses the Mix Methods Research method, which is a
Mochamad Farhan, Endang Rochyadi, Iding Tarsidi, Ranti Novianti   +3 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Spillover and crossover effects of exposure to work‐related aggression and adversities: A dyadic diary study

Aggressive Behavior, Volume 49, Issue 1, Page 85-95, January 2023., 2023
Abstract The past two decades have produced extensive evidence on the manifold and severe outcomes for victims of aggression exposure in the workplace. However, due to the dominating individual‐centered approach, most findings miss a social network perspective.
Alexander Herrmann, Jürgen Glaser, Tobias Greitemeyer   +2 more
wiley   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

COMP Report: CPQR technical quality control guidelines for use of positron emission tomography/computed tomography in radiation treatment planning

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Positron emission tomography with x‐ray computed tomography (PET/CT) is increasingly being utilized for radiation treatment planning (RTP). Accurate delivery of RT therefore depends on quality PET/CT data. This study covers quality control (QC) procedures required for PET/CT for diagnostic imaging and incremental QC required for RTP.
Ran Klein, Mike Oliver, Dan La Russa, John Agapito, Stewart Gaede, JeanPierre Bissonnette, Arman Rahmim, Carlos Uribe   +7 more
wiley   +1 more source

(Special) Education is Political; (Special) Education is Social Justice

Journal of Critical Thought and Praxis, 2020
Though treated as neutral and apolitical by schools, teachers, scholars, and administrators, special education is fraught with inequality and loaded language, and can function to segregate and disempower students. The debate over who is worthy of education–and what kind of education–is intimately tied to conceptions of dis/ability.
Lilly B. Padía, Rachel Elizabeth Traxler   +1 more
openaire   +3 more sources