Results 231 to 240 of about 14,226,764 (313)

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Free Open Access Medical Education (FOAM) in emergency medicine: use and perceived clinical relevance from a large cross-sectional survey. [PDF]

Int J Emerg Med
Fandler M, Doll T, Pott J, Turner W, Gotthardt P, Ehlers J, Nitsche J.   +6 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Associations Between Cerebral Amyloid Angiopathy, Cognitive Impairment, and Depressive Symptoms. [PDF]

Neurology
Nukala N, Muir RT, Beaudin AE, McCreary CR, Gee M, Nelles K, Saad F, Valencia J, Jickling GC, Guan DX, Ismail Z, Camicioli RM, Smith EE.   +12 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Bridging the Gap: Translated Medical Education to Support Cystic Fibrosis Centers From Non-English Speaking Countries. [PDF]

Pediatr Pulmonol
Smith C, Chadwick HK, Peckham DG, Hill K, Voivod O, Krasnyk M, Gökdemir Y, Gorgun I, Özdemircioğlu F, Makukh H, De Keyser H, Francis C, Štěpánková K, Szabo CE, Drevinek P.   +14 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Evaluating the quality, understandability, actionability, and readability of ChatGPT-generated patient information on overactive bladder: A cross-sectional study. [PDF]

Medicine (Baltimore)
Babayiğit M, Babayiğit M, Geyik S.
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Education Research: Educational Informatics: Characterizing Child Neurology Resident Clinical Experiences Using Electronic Health Record Data. [PDF]

Neurol Educ
Gottlieb-Smith R, Adams J, Bernson-Leung ME, Stamm B, Mai MV, Thompson Stone R, Troy ET, Xixis K, Majmudar-Sheth B, Dang LT, Dziorny AC.   +10 more
europepmc   +1 more source