Results 61 to 70 of about 1,088,681 (269)
Revue Internationale d’Éducation de Sèvres, 2011 In the last 10 years or so, the need to introduce changes to curricula has increasingly been evoked and which puts into question the pertinence of these changes as well as their coherence with the ideal of inclusive inclusion.
Renato Opertti, Leana Duncombe
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Academic Freedom in the Context of Societal Transformations: Based on Survey Data
Статистика УкраїниThe article examines the state and dynamics of academic freedom in the context of contemporary global challenges. The existing methodological toolkit for assessing university freedoms is analyzed, specifically the Academic Freedom Index (AFI), the ...
S. V. Zaiets
doaj +1 more source
Revue Internationale d’Éducation de Sèvres, 2011 Curricula are regularly subject to studies in comparative education, mainly on an international scale. While these studies are clearly worthwhile, the aim of this article is to demonstrate through a concrete example that comparative studies may also be ...
Sabine Soetewey +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Curriculum, entre modèle rationnel et irrationalité des sociétés
Revue Internationale d’Éducation de Sèvres, 2011 The author demonstrates the complementary nature of two different approaches to the concept of curricula. The article includes a table showing a rational model of the concept of a curriculum.
Philippe Jonnaert
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source