Results 61 to 70 of about 10,628 (217)
Revue Internationale d’Éducation de Sèvres, 2011 A number of African countries have previously entrusted teachers with the immense responsibility of supporting curriculum reform. Very few African institutions, including universities, offer training in curriculum development, even though funding is ...
Paul Mushi
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Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Que sont censés apprendre les élèves en Suisse ?
Revue Internationale d’Éducation de Sèvres, 2016 Determining what students should learn at school has evolved historically. In Switzerland, the traditional instrument for defining this is the programmes, that closely link education to teaching resources, and for which the cantons are responsible ...
Lucien Criblez
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Advances in Medical Education and PracticeGermanus Natuhwera,1,2 Peter Ellis,3 Eve Namisango2,4,5 1Clinical & Administration Departments, Hospice Africa Uganda, Kampala, Uganda; 2Education Department, Institute of Hospice and Palliative Care in Africa, Kampala, Uganda; 3Independent Nursing ...
Natuhwera G, Ellis P, Namisango E
doaj
Une histoire ancienne, de nouveaux défis
Revue Internationale d’Éducation de Sèvres, 2012 Literature teaching in France is rooted in a longstanding humanist tradition and meets a range of utiliarian, humanist and to a lesser extent rhetorical aims, which makes such lessons particularly complex to deliver. The body of works studied has shifted
Violaine Houdart-Merot
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
La lecture des œuvres complètes en contexte scolaire au Québec
Revue Internationale d’Éducation de Sèvres, 2012 In Quebec, the recent curricular reforms are very demanding in terms of the number of whole works to be read in pre-university training, but give teachers free rein for choosing which books.
Olivier Dezutter +3 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source