Results 51 to 60 of about 1,015,064 (290)

Integrating procurement, prescription, and resistance data to strengthen antimicrobial stewardship: insights from a public health institution in India

Frontiers in Microbiology
IntroductionSustained and sub-optimal antimicrobial use drives antimicrobial resistance (AMR), a major health systems challenge in low- and middle-income countries (LMICs) such as India.
Vinay Modgil, Sundeep Sahay, Sundeep Sahay, Arunima Mukherjee, Arunima Mukherjee, Rashi Banta, Neha Joshi, Rashmi Surial, Subhash Thakur, Suvodeep Mazumdar, Sneha Roychowdhury, Neelam Taneja   +11 more
doaj   +1 more source

La littérature à l’école en Chine

Revue Internationale d’Éducation de Sèvres, 2012
This article presents the nature, aim and status of yuwen lessons in Chinese schools, which teach the Chinese language, literature and cultures. It shows their importance in the general education system and how they fit into a humanist project. Analysing
Wei Chen, Li Qin
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

La réforme de la pédagogie universitaire au Danemark : le cas de l’apprentissage par problèmes

Revue Internationale d’Éducation de Sèvres, 2019
Since its inception, Aalborg University (AAU) in Denmark has been using problem-based learning (PBL). While the problem-based learning model has evolved over time, all of the university’s curricula are based on the shared principles of PBL, according to ...
Bettina Dahl, Jette Egelund Holgaard
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Engineering programme structure requirements for Bologna compliance [PDF]

, 2007
In 1999 twenty nine European countries have signed the Bologna Declaration to establish a common European higher education system as for the year 2010. Engineering Ireland has decided that the education standard for the title of CEng and MIEI should be ...
Olabi, Abdul-Ghani
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

An investigation into the adoption of CDIO in distance learning [PDF]

, 2008
The Conceive, Design, Implement and Operate Initiative (CDIO) uses integrated learning to develop deep learning of the disciplinary knowledge base whilst simultaneously developing personal, interpersonal, product, process and system building skills. This
Brodie, Lyn, Endean, Mark, Ferguson, Clive, Goodhew, Peter, Palmer, Stuart   +4 more
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source