Results 71 to 80 of about 1,017,767 (309)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
AntibioticsBackground: Antimicrobial resistance (AMR) poses a significant threat to public health, especially in low- and middle-income countries (LMICs), where surveillance infrastructure is underdeveloped.
Vinay Modgil +7 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
La scolarité obligatoire en Algérie : ambitions et défis
Revue Internationale d’Éducation de Sèvres, 2016 Algerian schooling promotes an educational project set out in the framework law on national education of 23 January 2008. On leaving compulsory education, the learner should have attained a level of mastery of basic languages in order to continue ...
Mina Tounsi
doaj +1 more source
An investigation into the adoption of CDIO in distance learning [PDF]
, 2008 The Conceive, Design, Implement and Operate Initiative (CDIO) uses integrated learning to develop deep learning of the disciplinary knowledge base whilst simultaneously developing personal, interpersonal, product, process and system building skills. This
Brodie, Lyn +4 more
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Some thoughts on civil engineering study programmes/Mintys apie statybos krypties studijų programas
Journal of Civil Engineering and Management, 1999 More than four hundred study programmes are registered in Lithuanian higher education institutions for undergraduate level, and the same number for postgraduate studies.
Algirdas E. Čižas
doaj +1 more source
A new paradigm for teacher education: supported, open teaching and learning at the Open University
, 2006 In this paper we draw on our experience over the last twelve years with three large scale distance education programmes for UK teachers to suggest factors which need to be considered by those embarking on large scale distance learning teacher education ...
Hutchinson, Steven, Wolfenden, Freda
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A comparative study of teaching forensics at a university degree level [PDF]
, 2006 Computer forensics is a relatively young University discipline which has developed strongly in the United States and the United Kingdom but is still in its infancy in continental Europe.
Anderson, Philip +6 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source