Results 51 to 60 of about 4,482,722 (250)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Publishing and perishing: The critical importance of educational design research [PDF]

, 2010
The outcomes of educational systems continue to lag far behind expectations at all levels, primary, secondary, and tertiary. Meanwhile, the sheer amount of educational research published in refereed journals has expanded enormously.
McKenney, Susan, Reeves, T.C., Herrington, J., Herrington, Jan, McKenney, S., Reeves, Thomas C., Susan McKenney, Jan Herrington, Reeves, Thomas, Thomas C. Reeves   +9 more
core   +4 more sources

OntoDup: Governance-Aware Entity Matching for Scholarly Knowledge Graph Deduplication

Information
Scholarly knowledge graphs integrate bibliographic records from heterogeneous sources and therefore require controlled, auditable deduplication. This paper presents OntoDup, an ontology-driven approach that models entity matching as a governed decision ...
Jorge Galán-Mena, Martín López-Nores, Daniel Pulla-Sánchez, Luis Fernando Guerrero-Vásquez, Juan Pablo Salgado-Guerrero   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

CooperAR: supporting the design and implementation of augmented inclusive educational scenarios

Frontiers in Education
There are sufficiently studied advantages of Augmented Reality (AR) in education. However, studies regarding the impact of AR in educational inclusion are still scarce; particularly, no methodologies that help educational institutions, particularly ...
Jairo Quintero, Silvia Baldiris, Silvia Baldiris, Jhoni Cerón   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

School exclusion and educational inclusion of pregnant young women

, 2014
This article analyses the school exclusion and subsequent educational inclusion of pregnant young women participating in a course of antenatal and key skills education at an alternative educational setting. It examines the young women's transitions from ‘
Rudoe, N.
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Inclusion in community educational psychology : a journal content analysis [PDF]

, 2021
Thesis (MEdPsych)--Stellenbosch University, 2021.ENGLISH SUMMARY : The fields of Community Psychology and Inclusive Education in Educational Psychology share many common values such as empowerment, social justice and inclusion.
Naidoo, Roegshana
core