Results 71 to 80 of about 4,482,722 (250)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A systematic review of whole class, subject based, pedagogies with reported outcomes for the academic and social inclusion of pupils with special educational needs in mainstream classrooms [PDF]

, 2009
Schools across the world have responded to international and national initiatives designed to further the development of inclusive education. In England, there is a statutory requirement for all schools to provide effective learning opportunities for all
Rix, J., Hall, K., Nind, M., Sheehy, K., Sheehy, Kieron, Collins, Janet, Wearmouth, Janice, Collins, J., Nind, Melanie, Wearmouth, J., Rix, Jonathan, Hall, Kathy   +11 more
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Good Faith and Effort? Perspectives on educational inclusion [PDF]

, 2005
This paper considers what might ‘count’ as educational inclusion from the perspectives of six women who are both mothers of and teachers of children with special educational needs (SEN) and/or disabilities.
Cole, Barbara
core  

Challenges and Opportunities of Multi-Grade Teaching: A Systematic Review of Recent International Studies

Education Sciences
Multigrade classrooms represent a widely extended educational modality in rural contexts and territories with low demographic density. This organizational model, in which a single teacher serves students from different levels in the same space, poses ...
Martina Ares-Ferreirós, José María Álvarez Martínez-Iglesias, Abraham Bernárdez-Gómez   +2 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Ethnomathématiques et décolonialité en éducation mathématique : une méta-synthèse qualitative

Contextes et Didactiques
This article presents a qualitative meta-synthesis of studies on decoloniality, ethnomathematics, and interculturality in mathematics education. Starting from the observation that mathematics teaching remains largely structured by Eurocentric frameworks ...
Saddo Ag Almouloud, Teodora Pinheiro Figueroa   +1 more
doaj   +1 more source

Educational inclusion in Paraguay: An analysis of the programmes aimed at access to education for young people in situations of vulnerability and social exclusion implemented in the last two governments 2008-2013 and 2013-2018.

Población y Desarrollo, 2017
The main objective of the work was to analyze the progresses and limitations of the public policies that were implemented by the governments between 2008-2013 and 2013-2018 concerning inclusive education of young people in Paraguay.
CLAUDIA SPINZI
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

An Axiological Analysis of Early Socio-Educational Services as Alternatives to the Inclusion of Children with Special Educational Needs

ACROSS
The article highlights the role of ethical and social values in the organisation of early socio-educational services for children with special educational needs.
Doina ADAȘAN
doaj   +1 more source