Results 81 to 90 of about 4,482,722 (250)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Effects of AI-Assisted Feedback via Generative Chat on Academic Writing in Higher Education Students: A Systematic Review of the Literature

Education Sciences
The use of generative chat in education has become widespread over the last four years, raising many questions about its use and the effects of AI on learning.
Claudio Andrés Cerón Urzúa, Ranjeeva Ranjan, Eleazar Eduardo Méndez Saavedra, María Graciela Badilla-Quintana, Nancy Lepe-Martínez, Andrew Philominraj   +5 more
doaj   +1 more source

Teachers' Mental Health and Their Involvement in Educational Inclusion. [PDF]

Behav Sci (Basel), 2022
Salinas-Falquez S, Roman-Lorente C, Buzica M, Álvarez J, Gutiérrez N, Trigueros R.   +5 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Inclusion in the City: setting the agenda for the first years of the Inclusion Initiative at LSE

, 2020
In November 2020 The Inclusion Initiative (TII) will launch at LSE. TII aims to bring behavioural science insights to firms to allow them to enhance the inclusion of all talent, and simultaneously produce academically rigorous and relevant research that ...
Robinson, Karina, Lordan, Grace
core   +3 more sources

Open instruction as a step towards a school-based heutagogical approach: a scoping review of the German concept of Offener Unterricht

Frontiers in Education
This paper addresses the conceptual ambiguity surrounding open instruction (Offener Unterricht) in German-speaking educational discourse. It situates the concept within current international discussions on self-determined learning, co-determination, and ...
David Hubner, David Hubner, Daniela Longhino, Daniela Longhino, Fabian Feyertag   +4 more
doaj   +1 more source

Educational Inclusion: biopolitical approach related to the bicentennial

Educação & Realidade, 2021
This paper studies the historical relationship between education and society based on a problematic element - inclusion. The commemoration of independence in American countries is addressed to show that different forms of educational inclusion seen today
Juan Carlos Echeverri-Alvarez
doaj  

Inclusive education through children's literature: reading to interiorize differences

MLS Educational Research, 2018
The meaning of Inclusive Education throughout the history of education in our country, has been taking different meanings and multiple forms. We are in a continuous process of change and it is necessary to train teachers with new skills, capable of ...
Lorena Pulido-Mantas, Susana Ruíz-Seisdedos   +1 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Teachers' and parents' attitudes towards inclusion in inclusive schools in Saudi Arabia [PDF]

Implementation of educational inclusion policy has been shown to be influenced by a range of factors, such as leadership, training opportunities, collaborative teamwork and, the focus of this thesis, parents’ and teachers’ attitudes towards inclusion ...
Alanazi, Mona
core