Results 81 to 90 of about 5,745,654 (298)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Investigate poor structural knowledge and develop and validation of the "behavioral signs of mathematical poor structural knowledge" test

مجله علوم روانشناختی, 2020
Background: Numerous studies have focused on how to build knowledge structure and the factors that affect it. However, research that examines the phenomenon of knowledge constructivism and the construction and validation of the "Mathematical Behavioral ...
Majid Dadashzade, Noorali Farrokhi, Asghar Minayi, Mohammad Asghari, Jamaladdin Koolayinejad   +4 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Development and Validation of Anxiety Questionnaire in Women with Polycystic Ovary Syndrome [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān
Introduction: Polycystic Ovary Syndrome (PCOS) is the most common hormonal disorder among women. This syndrome can be associated with an increased prevalence of mental health disorders.
Farzaneh Abdi, Enayatollah Zamanpour, Zohreh Rafezi   +2 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Large-Scale Item-Level Analysis of the Figural Matrices Test in the Norwegian Armed Forces: Examining Measurement Precision and Sex Bias

Journal of Intelligence
Figural matrices tests are common in intelligence research and have been used to draw conclusions regarding secular changes in intelligence. However, their measurement properties have seldom been evaluated with large samples that include both sexes ...
Fredrik Helland-Riise, Tore Nøttestad Norrøne, Björn Andersson   +2 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Examination of Teachers' Self-Efficacy Perceptions on Educational Measurement and Evaluation in Terms of Some Variables [PDF]

, 2016
Bu çalışmanın temel amacı, ilköğretim okulu ve liselerde görev yapan öğretmenlerin eğitimde ölçme ve değerlendirmeye yönelik özyeterlik algılarını cinsiyet, mesleki kıdem, eğitim durumu ve görev yapılan öğretim kademesi değişkenlerine göre incelemektir ...
Beyhan, Ömer, Baş, Gökhan, Gökhan Baş, Ömer Beyhan   +3 more
core   +1 more source

Investigating the Robustness of Text Mining Classification Algorithms: A Study of Algorithm and Expert Performance on Class-Inconsistent Data

Sakarya University Journal of Computer and Information Sciences
This study compares the classification accuracy of text mining algorithms for foreign language proficiency exam items. The dataset included 2,868 items from ÜDS English tests (2006–2012) across Natural and Applied Sciences (n=956), Health Sciences (n=956)
Ömay Çokluk-bökeoglu, Hüseyin Ataseven   +1 more
doaj   +1 more source