Results 71 to 80 of about 5,232,165 (252)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Systematic review of protective factors related to academic resilience in children and adolescents: unpacking the interplay of operationalization, data, and research method

Frontiers in Psychology
Identifying protective factors that promote academic resilience is vital. Nevertheless, due to the variations in the operationalizations of academic resilience, timeframes, data sources, and employed research methods, it remains unclear whether the ...
Wangqiong Ye, Nani Teig, Sigrid Blömeke
doaj   +1 more source

Examination of Teachers' Self-Efficacy Perceptions on Educational Measurement and Evaluation in Terms of Some Variables [PDF]

, 2016
Bu çalışmanın temel amacı, ilköğretim okulu ve liselerde görev yapan öğretmenlerin eğitimde ölçme ve değerlendirmeye yönelik özyeterlik algılarını cinsiyet, mesleki kıdem, eğitim durumu ve görev yapılan öğretim kademesi değişkenlerine göre incelemektir ...
Beyhan, Ömer, Baş, Gökhan, Gökhan Baş, Ömer Beyhan   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Foundational Competencies in Educational Measurement: A Rejoinder

What are foundational competencies in educational measurement? We published a framework for these foundational competencies in this journal (Ackerman et al.) and were grateful to receive eight commentaries raising a number of important questions about ...
Madison, Matthew J., Briggs, Derek C., Sinharay, Sandip, Russell, Michael, Rodriguez, Michael C., von Davier, Alina A., Wind, Stefanie A., Bandalos, Deborah L., Everson, Howard T., Lottridge, Susan M., Ackerman, Terry A., Ho, Andrew   +11 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Factors Affecting of Applying Results of Ordinary National Educational Test to Improve Educational Quality in the Three Southern Border Provinces [PDF]

, 2022
ศึกษาศาสตรมหาบัณฑิต (การวิจัยและประเมินผลการศึกษา), 2565The objectives of this research were: (1) investigate validity of the Ordinary National Educational Test results implementation model, (2) study the factors affecting the implementation of Ordinary ...
ภัทราวดี สีแก้วเขียว
core   +1 more source

Standardized Mean Differences: Not So Standard After All

Campbell Systematic Reviews
Meta‐analyses often use standardized mean differences (SMDs), such as Cohen's d and Hedges' g, to compare treatment effects. However, these SMDs are highly sensitive to the within‐study sample variability used for their standardization, potentially ...
Juyoung Jung, Ariel M. Aloe
doaj   +1 more source

Investigate poor structural knowledge and develop and validation of the "behavioral signs of mathematical poor structural knowledge" test

مجله علوم روانشناختی, 2020
Background: Numerous studies have focused on how to build knowledge structure and the factors that affect it. However, research that examines the phenomenon of knowledge constructivism and the construction and validation of the "Mathematical Behavioral ...
Majid Dadashzade, Noorali Farrokhi, Asghar Minayi, Mohammad Asghari, Jamaladdin Koolayinejad   +4 more
doaj