Results 31 to 40 of about 460,894 (268)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Anxiety Assessment in Methamphetamine - Sensitized and Withdrawn Rats: Immediate and Delayed Effects

Iranian Journal of Psychiatry, 2016
Objective: The anxiety profile in the stimulant-sensitized animals is not clear. Thus, this study was conducted to elucidate the effects of acute and chronic administration of methamphetamine (METH) on the anxiety profile.
Hossein Miladi-gorji, Atefeh Fadaei, Imanollah Bigdeli   +2 more
doaj  

The effect of educational program (based on BASNEF model) on quality of life and adherence to treatment in patients with myocardial infarction in Shahrekord, Iran

Journal of Education and Health Promotion, 2022
BACKGROUND: Myocardial infarction (MI) is one of the most common cardiovascular diseases affecting quality of life and adherence to treatment. This study aimed at assessing the impacts of an educational program based on the Belief, Attitude, Subjective ...
Hadi Hatami, Ali Hassanpour Dehkordi, Shahriyar Salehi Tali, Masoud Lotfizadeh, Haifeh Ganji   +4 more
doaj   +1 more source

Innovating education with an educational modelling language: two case studies [PDF]

Innovations in Education and Teaching International, 2006
The intent of this study was to investigate how to maximise the chances of success of an educational innovation—specifically one based on the implementation of the educational modelling language called EML. This language is both technically and organisationally demanding.
Sloep, Peter, Van Bruggen, Jan, Tattersall, Colin, Vogten, Hubert, Koper, Rob, Brouns, Francis; id_orcid 0000-0002-6240-2684, Van Rosmalen, Peter   +6 more
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Neonatal intensive care nursing curriculum challenges based on context, input, process, and product evaluation model: A qualitative study

Iranian Journal of Nursing and Midwifery Research, 2018
Background: Weakness of curriculum development in nursing education results in lack of professional skills in graduates. This study was done on master's students in nursing to evaluate challenges of neonatal intensive care nursing curriculum based on ...
Mansoureh Ashghali-Farahani, Fatemeh Ghaffari, Sara-Sadat Hoseini-Esfidarjani, Zahra Hadian, Robabeh Qomi, Helen Dargahi   +5 more
doaj   +1 more source

MEDIATIONS AND CITIZEN COMPETENCIES IN YOUTH [PDF]

Logos Ciencia & Tecnología, 2015
The purpose of this research is to understand the discourses that teachers show in their pedagogical practice for the development of citizenship competences in primary school students of the Calasanz School, as the field of research where it is observed ...
Blanca Mery Rolon, Mawency Vergel, Luisa Stella Paz Montes   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Educational Implications That Arise From Differing Models of Human Development and Their Repercussions on Social Innovation

Frontiers in Education, 2019
Social innovation aims for creating social value primarily while it recognizes that not all technology-based progress amounts to social progress. We think that this calls for a paradigm shift in how we understand education.
José Víctor Orón Semper, Kleio Akrivou, Germán Scalzo   +2 more
doaj   +1 more source