Results 51 to 60 of about 2,244,593 (310)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
From Stimulus to System: Using the ARRA to Serve Disadvantaged Jobseekers [PDF]
, 2009 This paper explores models and mechanisms for connecting low-skilled jobseekers to ARRA-related job opportunities--including community-benefit agreements, job linkage/first source hiring, and goals and standards for job creation and job quality--and for ...
David Fischer, Jeremy Reiss
core
Modelling online education [PDF]
, 2000 In this paper a model of an online education system is proposed. The proposed model involves three basic elements: a virtual community (composed of learners, tutors, technical support staff, experts and observers); a pool of learning materials, available on the web and sent via ordinary mail; and information and communication technologies used by the ...
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Educational Modelling Language
, 2010 This chapter is about an open learning technology specification called Educational Modelling Language (EML, 2000). EML has been designed within the Development-programma of the Open University of the Netherlands as a means to support re-use and interoperability.
Hermans, Henry +2 more
openaire +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The BETTER model-based counseling on sexual activity among women with multiple sclerosis [PDF]
PayeshObjective (s): Multiple sclerosis (MS) can have negative effects via several pathways on sexual activity. The growing trend of the disease in Iran and high prevalence in women (sex ratio: 2.3) intensifies the importance of this issue. It seems that women
Faezeh Ghafoori, Nahid Dehghan Nayeri
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
GMS Medizinische Informatik, Biometrie und Epidemiologie, 2010 Objectives: The Ontology of Bio-Medical Educational Objectives (OBEO) is a formal ontology for the annotation of educational objective catalogues and learning object resources to improve their usability. OBEO has been designed to allow semantic retrieval
Boeker, Martin +3 more
doaj